Articles

Spray-assisted drop formation liquid-phase microextraction for the determination of sertraline in environmental water samples with matrix-matching calibration in GC–MS

Sertraline is used as an antidepressant drug for the treatment of psychiatric disorders, including anxiety and depression. In the current study, a simple and effective method was developed for the sensitive mo...

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Isotopic distribution of bioavailable Sr, Nd, and Pb in Chungcheongbuk-do Province, Korea

Mapping the distribution of bioavailable isotope ratios across landscapes serves as an efficient geochemical tool for delineating the origins and migration trajectories of humans and animals. Chungcheongbuk-do...

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Exploring the feasibility of a single-protoplast proteomic analysis

Recent advances in high-resolution mass spectrometry have now enabled the study of proteomes at the single-cell level, offering the potential to unveil novel aspects of cellular processes. Remarkably, there ha...

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Comparative stagewise mapping of trace elements using ICP-OES in five Ayurvedic Marine Drugs highlights their posologic and clinical implications

Rasashastra, an Ayurvedic pharmaceutical branch, scientifically converts natural resources into palatable therapeutic dosage forms. Ayurvedic Marine Drugs (AMD) are mainly calcium carbonate/ calcite, but in Ayurv...

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Gaseous ozone inactivation of Bacillus atrophaeus spores on ceramic and porcelain tiles

In this study, we investigated the ozone inactivation efficiency of Bacillus atrophaeus spores attached to various tile surfaces. Eight different types of tiles were employed, considering factors such as porosity...

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Integrating the controlled evaporation mixer with cavity ring-down spectroscopy for enhanced water vapor isotope calibration

Accurate measurement of water vapor isotopes (δ¹⁸O and δ²H) is fundamental for advancing our understanding of the hydrological cycle and improving hydrological model accuracy. This study introduces an innovative ...

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Design of point-of-care electrochemical sensor for therapeutic drug monitoring of ofloxacin in biological fluids

A disposable screen-printed sensor has been crafted specifically for therapeutic drug monitoring purposes, particularly for detecting ofloxacin in biological fluids. To enhance selectivity toward ofloxacin, a ...

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Exonuclease III assisted exponential amplification reaction (EXPAR) for specific miRNA-155 analysis during post-anesthetic nursing

The persistent obstacle in precise and sensitive identification of microRNAs (miRNAs) pertains to the advancement of expeditious and effective isothermal amplification methodologies suitable for point-of-care ...

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NMR structure and functional studies of the fourth FAS1 domain of human periostin

Periostin is a matricellular protein that consists of several structural and functional domains, including EMILIN-like, four internal repeat fasciclin1 (FAS1) domains, and a carboxyl-terminal variable domain. ...

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Comparative examination of analytical instruments for detecting pentachlorophenol in wood and environmental samples

Pentachlorophenol (PCP) is a manmade chemical that is widely present in the environment and is mostly used as a wood preservative. Therefore, to conduct remediation studies, it is imperative to determine the m...

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Development and validation of an LC–MS/MS method for the determination of BLU-945, a fourth-generation EGFR tyrosine kinase inhibitor, in rat and mouse plasma: application to a pharmacokinetic study in rats

BLU-945, a new-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is a potential drug candidate for the treatment of non-small-cell lung cancer (NSCLC) in patients with mutatio...

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Detection of bladder tumor cells using motion features in urine

Urinary exfoliated tumor cells have emerged as promising biomarkers for predicting, diagnosing, and guiding therapy in bladder cancer. Several methodologies based on biological and physical differences between...

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Nail fold capillaroscopy as a potential tool to evaluate breast tumor

It is necessary to verify whether nail fold capillaroscopy can be utilized for the early detection of breast cancer. To establish this technology, an animal model was developed, utilizing mice for nail fold ob...

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Raman spectroscopic comparison of zearalenone and its derivatives for non-destructive rapid detection

Raman spectroscopy is used to investigate the absorption and dispersion of zearalenone (ZEN) and its derivatives. The C=C stretching vibration modes of ZEN and zearalenol (ZENOL) were appeared at 975–990 cm⁻¹. Th...

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Spectroscopic and antibacterial activities of cobalt and nickel nanoparticles: a comparative analysis

This study aimed to compare the spectroscopy, morphological, electrocatalytic properties, and antibacterial activities of cobalt nanoparticles (CoNPs) with nickel nanoparticles (NiNPs). Cobalt nanoparticles an...

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Assessing the interplay of contrast, defocus, and resolution in cryo-EM: a benchmark experiment for limited dataset screening

The selection of defocus ranges for small datasets in cryo-electron microscopy (cryo-EM) is under-researched. We present a comprehensive benchmark experiment that aimed to evaluate the relationship between con...

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Dynamics of acyl carrier protein in de novo fatty acid synthesis by Enterococcus faecalis based on NMR spectroscopy and molecular dynamics simulation

Fatty acid synthesis (FAS) is essential for the production of biological components such as cell membrane building blocks and metabolism-related compounds. There are two types of bacterial FAS: de novo FAS and...

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Target recognition-initiated allosteric probe-based multiple signal amplification strategy for sensitive and direct Pseudomonas aeruginosa detection

Pseudomonas aeruginosa (P. aeruginosa), a kind of gram-negative pathogenic bacteria, are causative agents of severe infections, such as lower respiratory tract infections in children and cancers. Detecting low le...

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Fast, accessible and reliable method for elemental analysis of metals in solution by ED-XRF spectroscopy

The measurement of metals in solution is usually performed using inductive coupled plasma hyphenated techniques or atomic absorption. Although very sensitive and accurate, these analytical techniques are quite...

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Development of non-destructive isotope measurement of the natural galena (PbS) using negative muon beams

In Earth and planetary science, Pb isotopic composition is well known to play a key role in deciphering the origin and evolution of materials because they provide unique chronological and/or indigenous regiona...

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SIMS study of fine-scale distribution of U, Th and Pb in meteorites

We report developing a procedure for measuring concentrations of U, Th and Pb (including all natural Pb isotopes) to establish the distribution of these elements in meteorite minerals and correctly interpret P...

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Aptamer-based protein molecule detection via cyclic reverse transcription coupling with self-priming hairpin-triggered CRISPR-Cas12a system

Protein biomarkers (e.g. thrombin) are of great significance for the biological process of the organism, and its aberrant expression is closely associated with the development of diseases. With thrombin, a serine...

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Assessment of the antibacterial efficacy of silver nanoparticles-based Artemisia annua against methicillin-resistant Staphylococcus aureus-infected lung tissues in albino rats

The production of alternative and effective medicines is crucial given that antibiotic resistance is currently a global health concern. Several biochemical identification tests were used to screen for Staphylococ...

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Hf-W dating of zircon in mesosiderite with high-pressure sintered standard

New standard zircons applicable to in situ analysis of Hf/W ratio by Nanoscale secondary ion mass spectrometer (NanoSIMS) were prepared and applied to Hf-W dating of a differentiated meteorite classified as me...

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Advances in mass spectrometry-based approaches for characterizing monoclonal antibodies: resolving structural complexity and analytical challenges

Mass spectrometry (MS)-based intact mass analysis and structural characterization of biotherapeutic proteins such as monoclonal antibodies (mAbs) are a crucial characterization approach from upstream drug deve...

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Sample size and the limits to precision in Pb-isotopic dating by ID-TIMS

Using isotope analysis of ancient (4555 Ma) radiogenic Pb by ID-TIMS as an example, I evaluate the sample size required to achieve the target precision of the ²⁰⁷Pb/²⁰⁶Pb ratio 0.007% (2σ), corresponding to the u...

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Direct and accurate miRNA detection based on CRISPR/Cas13a-triggered exonuclease-iii-assisted colorimetric assay

The abnormally expressed microRNAs (miRNAs) serve as crucial indicators for disease diagnosis and are strongly associated with the progression of various diseases. The quantification of miRNAs is highly signif...

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Performance assessment of activated carbon thermally modified with iron in the desulfurization of biogas in a static batch system supported by headspace gas chromatography

A static batch arrangement composed of anti-leak vials coupled to gas chromatography is proposed as a complementary system for performance assessment of biogas desulfurization by adsorption. For testing, a mod...

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Nanoscale analysis of noble gas in solids

Noble gases are useful tracers for geochemistry, used to elucidate the origin and evolution of the solar system and planets. Noble gas analyses have been limited to bulk and spot analyses of solids and have ye...

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Electron microprobe dating of lunar zirconolite

Zirconolite is an accessary mineral occurred in the lunar basaltic and granitic rocks and contains relatively high contents of U, Th, and Pb, which is attractive for age dating. However, very few studies have ...

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Feasibility of UV–Vis spectroscopy combined with pattern recognition techniques to authenticate the medicinal plant material from different geographical areas

The correct identification and authentication of medicinal plants material is a crucial task that ensures quality and prevent adulteration. The use of UV–Vis spectroscopy with principal component analysis (PCA...

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Sensitive and reliable miRNA analysis based on cyclic reverse transcription and CRISPR-Cas12a-assisted signal cycle

MicroRNAs (miRNAs), a category of small molecules that possess significant regulatory capabilities, have been extensively employed as biomarkers in the domain of biosensing to facilitate the early detection of...

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Laser ablation MC-ICPMS U-Th and U-Th-Pb dating of Quaternary zircons from Jeju Island, Korea

Laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) emerged in the mid-1980s and rapidly became a crucial dating tool. The advent of femtosecond LA systems has substantially reduced volatili...

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Isotopic variations of Sm, Gd, Er and Yb found in planetary materials caused by neutron-capture reactions in nature

The isotopic shifts of ¹⁴⁹Sm–¹⁵⁰Sm and ¹⁵⁷Gd–¹⁵⁸Gd have often been observed in meteorites and lunar surface materials, because they result from the neutron-capture reactions associated with secondary neutrons pro...

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Microstructural and microchemical analysis of zircon in a syenite lithic fragment from Ulleung Island volcano, South Korea

The intricate textural patterns commonly observed in metamorphosed and recrystallized zircon (ZrSiO₄) underscore the crucial necessity of understanding the underlying mechanisms governing their formation to ensur...

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New development of compact magnetic separator for on-site material screening in various geological survey

Magnetic separation has been recognized as a valuable technique for extracting or separating target materials from mixed heterogeneous particles. In conventional geological research, it has been used to separa...

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Molecularly imprinted polymers as solid-phase and dispersive solid-phase extraction sorbents in the extraction of antiretroviral drugs in water: adsorption, selectivity and reusability studies

The antiretroviral drugs (ARVDs) have been reported to be among the emerging water pollutants as a results attention is being paid on their analysis. This work therefore explored for the first time the multi-t...

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Microanalysis and mineralogy of Asian and Saharan dust

Mineral dust is transported over long distances from desert sources, interacting with Earth environments. The mineralogy and microstructures of individual dust particles are required to understand the interact...

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Geochemical and cosmochemical application of microanalysis

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Simultaneous determination of ethyl glucuronide, cocaine, cocaethylene, and benzoylecgonine in hair by using LC–MS/MS

Alcohol and cocaine (COC) are commonly co-used drugs that cause addiction and have harmful effects. Their abuse may threaten the health of the abuser and public safety by causing serious accidents or crimes. T...

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Metabolomics characterization of two saffron from Iran and China using GC–MS and LC–MS methods

Saffron is a medicinally important species of the Iridaceae family. Saffron’s quality depends on the concentration of secondary metabolites. In this study, GC–MS and LC–MS were utilized to dissect the differen...

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Method development for ¹⁴C-labeling of IgG antibodies in preparation for clinical trials

Carbon-14 (¹⁴C) labeling is a standard technology for tracing molecules and providing their pharmacokinetic profiles. However, its primary focus has been on small molecules, with limited application to biomacromo...

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Novel plasma-polymerized coating facilitates HeLa cell spheroid formation, exerting necroptosis via β-cyclodextrin-encapsulated resveratrol

Beta-cyclodextrins (β-CDs) comprise a pore for accommodating resveratrol (Res), thereby boosting its bioavailability. Res-incorporated β -CD (Res/CD) may be cytotoxic against both normal and cancer cells. Here...

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Artificial intelligence and quantum cryptography

The technological advancements made in recent times, particularly in artificial intelligence (AI) and quantum computing, have brought about significant changes in technology. These advancements have profoundly...

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Glyphosate detection via a nanomaterial-enhanced electrochemical molecularly imprinted polymer sensor

Glyphosate (GLY) is a widely used herbicide with an important role in agriculture. It effectively controls weeds, enhancing agricultural yield and product quality. However, its use raises significant concerns ...

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A simple and label-free proximity-catalytic hairpin reaction-based method for sensitive and miRNA analysis

Aberrant expression of microRNAs (miRNAs) has been shown to be linked to several crucial biological processes, including as carcinogenesis, metastasis, and progression. The advancement of innovative miRNA dete...

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Nonlinear dimensionality reduction based visualization of single-cell RNA sequencing data

Single-cell multi-omics technology has catalyzed a transformative shift in contemporary cell biology, illuminating the nuanced relationship between genotype and phenotype. This paradigm shift hinges on the und...

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Quantification of bone surface textures: exploring a new method of ontogenetic ageing

Identification of ontogenetic age classes plays an important role in the fields of zoology, palaeontology and archaeology, where accurate age classifications of (sub)fossil remains are a crucial component for ...

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Synthesis and evaluation of small molecule-based derivatives as inhibitors of polo-box domain of polo-like kinase-1

Polo-like kinase 1 (Plk1) is an important mitotic protein. In particular, this protein is highly overexpressed in many types of tumors and has been identified as a potential biomarker for the treatment and dia...

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