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Table 2 Concentration of opioids and benzodiazepines in patient urine samples

From: Stability study of opioids and benzodiazepines in urine samples by liquid chromatography tandem mass spectrometry

Patient Prescriptions Expected compounds Detected compounds and metabolites LLOQ (ng/mL) HLOQ (ng/mL) Concentrations [ng/mL] Change c
Initial a Final b  
I OxyIR® Morphine, oxycodone 6-Acetylmorphine 3 192 17 9
Hydromorphone 100 6,400 639 900 +
Morphine 100 6,400 (91,475) (146,125)  
Oxycodone 50 3,200 (8,525) (12,346)  
Oxymorphone 100 6,400 1,432 2,426 +
Nordiazepam 80 5,120 4,147 4,092
Oxazepam 80 5,120 4,830 4,684
  80 5,120 3,630 2,469
II Opana®, oxycodone Oxymorphone, oxycodone Buprenorphine 10 640 23 24 +
Norbuprenorphine 20 1,280 94 86
Oxycodone 50 3,200 (13,076) (23,402)  
Oxymorphone 100 6,400 (10,109) (15,006)  
Alpha hydroxyl alprazolam 80 5,120 620 528
Alprazolam 80 5,120 163 154
III Lortab®, Percocet®, Soma®, Valium® Hydrocodone, acetaminophen, oxycodone, carisoprodol, diazepam Hydrocodone 100 6,400 5,988 4,801
Hydromorphone 100 6,400 207 259 +
Oxycodone 50 3,200 3,197 2,941
Oxymorphone 100 6,400 365 774 +
Alpha hydroxyl alprazolam 80 5,120 133 57
Nordiazepam 80 5,120 1,733 1,533
Oxazepam 80 5,120 (6,604) (5,646)  
Temazepam 80 5,120 3,891 2,953
IV Endocet®, Soma®, Xanax® Oxycodone, acetaminophen, carisoprodo, alprazolam Oxycodone 50 3,200 1,413 1,182
Oxymorphone 100 6,400 491 803 +
Alpha hydroxyl alprazolam 80 5,120 253 161
Alprazolam 80 5,120 1,003 890
Meprobamate 100 6,400 (14,016) (13,838)  
  1. LLOQ, lower level of quantification (level 1); HLOQ, higher level of quantification (level 6). aInitial concentration of the detected compounds; bconcentration of the detected compounds after 30 days of storage at 4°C; cchange in the compound concentration after storage: increased (+), decreased (−).