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Journal of Analytical Science and Technology
Fig. 8 | Journal of Analytical Science and Technology

Fig. 8

From: Advances in mass spectrometry-based approaches for characterizing monoclonal antibodies: resolving structural complexity and analytical challenges

Fig. 8

Online ECD HIC-MS/MS analysis of deglycosylated mAb2 on a 12 T solariX XR FT-ICR MS. a HIC chromatogram and spectrum of mAb2 fragment ions and charge reduced ions. b CDR H3 and L3 (red highlighted regions) c Crystal structure of the mAb2 Fab region (PDB: 5K8A). The CDRs fragmented by ECD (H3 and L3) are highlighted in red, and the other CDRs are highlighted in blue (H1, H2, L1, and L2). Reprinted with permission from Ref (Chen et al. 2018a). Copyright 2017 American Chemical Society

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