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Journal of Analytical Science and Technology
Fig. 19 | Journal of Analytical Science and Technology

Fig. 19

From: Advances in mass spectrometry-based approaches for characterizing monoclonal antibodies: resolving structural complexity and analytical challenges

Fig. 19

ESI-TOF MS spectra of unstressed (top) and pH-stressed (bottom) IgG solutions, without HP-SEC separation. In both unstressed and pH-stressed samples, peaks between mass range of 5000–7000 represent different charged states of IgG monomers. The unstressed IgG spectrum consists of 99.8% monomers and 0.2% dimers (top inset). The pH-stressed IgG spectrum consists of 90.1% monomers, 9.5% dimer and 0.4% trimer (bottom inset). Adapted from Ref (Kükrer et al. 2010)

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