Fig. 13

Average signal (% TIC) of matched fragments obtained under the two conditions (i) amino acid residue position in the heavy (top) and (ii) light (bottom) chains. Light blue indicates the intrachain disulfide bonds, whereas pink indicates the interchain disulfide bonds. The Venn diagrams indicate the number of separate and overlapping relationships broken under each situation. Reprinted with permission from Ref (Lodge et al. 2020). Copyright 2020 American Chemical Society