Quantification of venadaparib, a novel PARP inhibitor, in the rat and dog plasma using liquid chromatography/tandem mass spectrometry

Journal of Analytical Science and Technology

Table 5 Summary of systemic PK parameters following oral administration of VEN to rats and dogs

Pharmacokinetic parameters	Rat¹		Dog²
	Male	Female	Male	Female
	Mean		Mean ± SD
Dose (mg/kg)	30.0		0.50
T_max (h)	0.333	1.00	0.583 ± 0.342	0.583 ± 0.342
C_max (ng/mL)	1,130	4160	120 ± 61	156 ± 54
T_1/2 (h)	1.92	1.88	1.43 ± 0.64	1.72 ± 0.29
AUC_0→t (ng·h/mL)	5,310	12,900	243 ± 111	361 ± 88
AUC_0→∞ (ng·h/mL)³	5,430	13,100	267 ± 169	369 ± 98

¹Three replicates: Each rat covered different regions in the time profile and, as results, the calculation of the standard deviation (SD) was not possible
²Six replicates
³AUC from time of dosing extrapolated to infinity