Table 2 Accuracy and precision of the assay for VEN in plasma samples from the rat and dog
Batch | Theoretical concentration (ng/mL) | ||||
|---|---|---|---|---|---|
1 | 3 | 300 | 800 | 8003 | |
Rat plasma | |||||
(A) Within-run accuracy and precision | |||||
Mean estimated concentration | 1.07 | 3.01 | 301 | 802 | 800 |
RE, %1 | 7.0 | 0.3 | 0.3 | 0.3 | 0.0 |
CV, %2 | 7.3 | 2.4 | 1.4 | 2.9 | 3.3 |
(B) Between-run accuracy and precision | |||||
Mean estimated concentration | 1.05 | 3.09 | 295 | 802 | |
RE, % | 6.9 | 9.0 | 4.2 | 5.9 | |
CV, % | 5.0 | 3.0 | − 1.7 | 0.3 | |
Dog plasma | |||||
(A) Within-run accuracy and precision | |||||
Mean estimated concentration | 1.06 | 3.05 | 308 | 828 | 795 |
RE, % | 6.0 | 1.7 | 2.7 | 3.5 | − 0.6 |
CV, % | 3.6 | 3.3 | 1.7 | 4.2 | 2.4 |
(B) Between-run accuracy and precision | |||||
Mean estimated concentration | 1.02 | 2.98 | 296 | 784 | |
RE, % | 2.0 | − 0.7 | − 1.3 | − 2.0 | |
CV, % | 7.6 | 9.0 | 7.4 | 7.8 | |