Table 2 Repeatability and reproducibility results for pantothenic acid, pyridoxine, biotin and folic acid analysis in homogenized multivitamin tablet samples, obtained by the developed ID–LC/MS method
From: Development of a certified reference material for the analysis of vitamins in multivitamin tablets
Period | Subsample No | Measurement results | |||
|---|---|---|---|---|---|
Pantothenic acid (g/kg) | Pyridoxine (g/kg) | Biotin (mg/kg) | Folic acid (mg/kg) | ||
1st | Subsample 1–1 | 24.85 ± 0.22a | 21.84 ± 0.47 | 25.41 ± 0.45 | 108.4 ± 1.9 |
Subsample 1–2 | 25.11 ± 0.42 | 21.64 ± 0.46 | 25.80 ± 0.18 | 108.0 ± 2.1 | |
Subsample 1–3 | 24.99 ± 0.29 | 21.61 ± 0.45 | 25.86 ± 0.39 | 109.7 ± 2.2 | |
Average | 24.98 ± 0.29 | 21.70 | 25.69 ± 0.28 | 108.7 ± 2.1 | |
Standard deviation | 0.13 (0.52 rel%b) | 0.12 (0.55 rel%) | 0.24 (0.94 rel%) | 0.91 (0.84 rel%) | |
2nd | Subsample 2–1 | 25.90 ± 0.98 | 21.39 ± 0.79 | 25.91 ± 0.55 | 109.9 ± 3.3 |
Subsample 2–2 | 25.76 ± 1.05 | 21.47 ± 0.78 | 25.96 ± 0.52 | 108.4 ± 3.4 | |
Subsample 2–3 | 25.82 ± 0.96 | 21.55 ± 0.78 | 25.89 ± 0.54 | 109.9 ± 2.8 | |
Average | 25.83 ± 0.98 | 21.47 ± 0.78 | 25.92 ± 0.53 | 109.4 ± 3.0 | |
Standard deviation | 0.07 (0.28 rel%) | 0.08 (0.37 rel%) | 0.04 (0.17 rel%) | 0.86 (0.78 rel%) | |
Average | 25.40 | 21.59 | 25.81 | 109.1 | |
Standard deviation among period | 0.60 (2.36 rel%) | 0.17 (0.77 rel%) | 0.17 (0.63 rel%) | 0.49 (0.45 rel%) | |