Table 1 List of 23 proteins represented by cluster 4 expression upregulated by 6-OHDA and downregulated by MPP+ in Fig. 4
UniProt accession | Protein description | Gene symbol | 6-OHDA versus control | MPP+ versus control | ||
|---|---|---|---|---|---|---|
Log2 fold change | p value | Log2 fold change | p value | |||
Q13526 | Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 | PIN1 | 0.588 | 3.37E−02 | − 0.871 | 4.21E−02 |
H0Y6Y8 | 39S ribosomal protein L43, mitochondrial | MRPL43 | 1.120 | 4.57E−03 | − 1.659 | 1.14E−02 |
P52298 | Nuclear cap-binding protein subunit 2 | NCBP2 | 0.805 | 2.85E−02 | − 0.710 | 1.79E−02 |
Q9BT09 | Protein canopy homolog 3 | CNPY3 | 1.051 | 3.39E−04 | − 1.009 | 3.04E−02 |
J3KRA9 | Serine/threonine-protein kinase SMG1 | SMG1 | 0.650 | 2.74E−02 | − 2.869 | 4.63E−03 |
Q9Y2R5 | 28S ribosomal protein S17, mitochondrial | MRPS17 | 0.648 | 2.60E−02 | − 1.713 | 3.09E−02 |
O75475 | PC4 and SFRS1-interacting protein | PSIP1 | 1.010 | 1.93E−02 | − 5.273 | 1.98E−03 |
Q9Y5M8 | Signal recognition particle receptor subunit beta | SRPRB | 0.761 | 8.17E−03 | − 1.112 | 2.01E−03 |
O43678 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | NDUFA2 | 0.647 | 4.00E−02 | − 1.172 | 8.15E−04 |
Q14061 | Cytochrome c oxidase copper chaperone | COX17 | 1.225 | 4.41E−02 | − 1.911 | 1.69E−03 |
Q8TC12 | Retinol dehydrogenase 11 | RDH11 | 0.638 | 4.35E−02 | − 1.457 | 1.50E−03 |
Q9NRX2 | 39S ribosomal protein L17, mitochondrial | MRPL17 | 2.367 | 1.23E−02 | − 2.084 | 5.06E−03 |
Q99986 | Serine/threonine-protein kinase VRK1 | VRK1 | 0.673 | 2.23E−02 | − 3.748 | 4.41E−03 |
Q9P287 | BRCA2 and CDKN1A-interacting protein | BCCIP | 0.686 | 7.90E−03 | − 0.810 | 1.39E−05 |
P18754 | Regulator of chromosome condensation | RCC1 | 0.740 | 3.14E−03 | − 1.571 | 4.93E−05 |
O43920 | NADH dehydrogenase [ubiquinone] iron–sulfur protein 5 | NDUFS5 | 1.447 | 3.68E−02 | − 1.370 | 1.23E−02 |
Q6P1L8 | 39S ribosomal protein L14, mitochondrial | MRPL14 | 1.546 | 3.94E−02 | − 2.886 | 1.52E−06 |
O00483 | Cytochrome c oxidase subunit NDUFA4 | NDUFA4 | 1.423 | 8.74E−03 | − 2.612 | 1.57E−05 |
Q8WWY3 | U4/U6 small nuclear ribonucleoprotein Prp31 | PRPF31 | 0.611 | 4.62E−03 | − 0.718 | 2.88E−03 |
Q5JTJ3 | Cytochrome c oxidase assembly factor 6 homolog | COA6 | 1.410 | 3.54E−03 | − 0.617 | 3.67E−02 |
O95747 | Serine/threonine-protein kinase OSR1 | OXSR1 | 0.735 | 1.17E−02 | − 0.619 | 1.04E−02 |
Q8N6T3 | ADP-ribosylation factor GTPase-activating protein 1 | ARFGAP1 | 0.587 | 1.18E−03 | − 1.546 | 9.55E−03 |
P14854 | Cytochrome c oxidase subunit 6B1 | COX6B1 | 1.696 | 4.71E−05 | − 2.884 | 5.69E−03 |