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Journal of Analytical Science and Technology
Fig. 4. | Journal of Analytical Science and Technology

Fig. 4.

From: Comparative proteomics study of mitochondrial electron transport system modulation in SH-SY5Y cells following MPP+ versus 6-OHDA-induced neurodegeneration

Fig. 4.

6-OHDA and MPP+ reversibly altered the expression of electron transport proteins associated with mitochondrial dysfunction in SH-SY5Y cells. A Heatmap analysis of four conditions (6-OHDA control group, 6-OHDA treatment, MPP+ control group, and MPP+ treatment) for 100 proteins with p < 0.05 and fold change > 1.5 in 6-OHDA and MPP+-treated SH-SY5Y cells shows clusters enriched in each proteome set. B STRING protein–protein interaction analysis for 23 proteins represented by cluster 4 upregulated by 6-OHDA and downregulated by MPP+. 6-OHDA 6-hydroxydopamine, MPP+ 1-methyl-4-phenylpyridinium

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