Fig. 2

A comprehensive overview of proteomics. A Venn diagram showing the number of identified proteins in each of the following four proteome sets: 6-OHDA control, 6-OHDA-treated, MPP+ control, and MPP+-treated. Volcano plot shows the differentially regulated proteins in B 6-OHDA-induced neurodegeneration in SH-SY5Y cells and C MPP+-induced neurodegeneration in SH-SY5Y cells. The horizontal coordinate (X-axis) represents the difference in fold change (logarithmic transformation at the base of 2), and the vertical coordinate (Y-axis) represents the significant difference in p value (logarithmic transformation at the base of 10). Proteins that are onefold significantly upregulated are presented as red dots, while those that are onefold downregulated are shown as blue dots. Proteins with a fold change less than onefold change are presented as gray dots. Black dots represent proteins that do not have a significant fold change. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article). 6-OHDA 6-hydroxydopamine; MPP+ 1-methyl-4-phenylpyridinium