Performance comparison between solid phase extraction and magnetic carbon nanotubes facilitated dispersive-micro solid phase extractions (Mag-CNTs/d-µSPE) of a cyanide metabolite in biological samples using GC–MS

Journal of Analytical Science and Technology

Table 4 For the two Mag-CNTs/d-µSPE methods, the mean bias (%), and the between-run and within-run precision (%CV), and extraction efficiency (%) of the QC samples were determined at low (30 ng/mL for synthetic urine, 180 ng/mL for bovine blood), medium (500 ng/mL), and high concentration (800 ng/mL) of synthetic urine and bovine blood samples over five separate sets (n = 3)

Methods	Matrices	QC samples	Mean Bias (%, n = 15; n = 9 for SPE)	Between-run precision (%CV, n = 15; n = 9 for SPE)	Max within-run precision (%CV, n = 3)	Extraction efficiency (%, n = 15; n = 9 for SPE)
Mag-CNTs-COOH/d-µSPE	Synthetic Urine	Low	− 8.30	10.63	12.7	91.70
		Medium	3.06	4.60	4.18	103.06
		High	1.72	2.58	3.53	101.72
	Bovine Blood	Low	3.68	3.32	4.20	103.70
		Medium	1.79	6.33	9.44	101.79
		High	0.72	2.95	5.47	100.73
Mag-CNTs-SO₃H/d-µSPE	Synthetic Urine	Low	− 8.55	9.17	7.45	91.45
		Medium	− 4.61	7.50	7.80	95.39
		High	− 2.63	10.21	10.44	97.37
	Bovine Blood	Low	2.55	8.04	16.47	102.55
		Medium	2.95	8.32	10.29	102.95
		High	2.09	10.39	9.22	102.09
SPE	Bovine Blood	Low	− 5.92	3.14	4.26	94.08
		Medium	5.24	7.73	9.35	105.23
		High	0.91	2.95	5.44	100.91

For SPE method, the parameters were determined at low (75 ng/mL), medium (500 ng/mL), and high (800 ng/mL) concentration in bovine blood samples over three sets (n = 3)