Table 3 Validation parameters for 60 veterinary antibiotic residues at three concentration levels in blank milk samples and milk powder samples.
Peak | Compound | Sample | Linear range (μg/L) | Spiking level (μg/kg) | Recovery (Mean ± SD%) | Intra-day (RSD, n = 6) | Inter-day (RSD, n = 3) | LOD (μg/kg) | LOQ (μg/kg) | R2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Sulfaguanidine | Milk | 0.5–20 | 5 | 10 | 20 | 105.4 ± 8.6 | 101.8 ± 6.5 | 99.4 ± 5.4 | 8.5 | 9.2 | 6.6 | 9.2 | 9.0 | 5.5 | 0.5 | 5.0 | 0.9957 |
Milk powder | 81.2 ± 8.6 | 91.2 ± 6.6 | 98.2 ± 2.3 | 8.6 | 6.4 | 2.5 | 9.5 | 7.5 | 3.1 | 0.5 | 5.0 | 0.9901 | ||||||
2 | 2-Methyl-5-nitroimidazole | Milk | 0.5–20 | 5 | 10 | 20 | 104.4 ± 5.5 | 107.1 ± 4.2 | 90.6 ± 0.5 | 5.4 | 4.4 | 0.4 | 6.0 | 2.4 | 2.0 | 0.5 | 5.0 | 0.9965 |
Milk powder | 78.0 ± 7.8 | 87.8 ± 6.9 | 97.6 ± 2.2 | 7.5 | 6.4 | 2.0 | 8.9 | 7.1 | 3.3 | 0.5 | 5.0 | 0.9959 | ||||||
3 | Metronidazole | Milk | 0.5–20 | 5 | 10 | 20 | 62.1 ± 7.5 | 86.4 ± 3.8 | 90.3 ± 2.5 | 8.0 | 4.2 | 3.2 | 9.7 | 5.9 | 4.8 | 0.5 | 5.0 | 0.9932 |
Milk powder | 70.5 ± 4.6 | 95.5 ± 4.5 | 97.2 ± 1.7 | 4.9 | 4.4 | 2.1 | 5.8 | 5.7 | 2.9 | 0.5 | 5.0 | 0.9930 | ||||||
4 | Cefapirin | Milk | 1–100 | 10 | 20 | 50 | 101.2 ± 7.3 | 97.6 ± 5.8 | 94.0 ± 4.2 | 6.5 | 5.4 | 4.8 | 8.4 | 6.1 | 5.2 | 1.0 | 10.0 | 0.9919 |
Milk powder | 65.9 ± 9.0 | 80.5 ± 6.2 | 86.4 ± 3.8 | 9.5 | 6.8 | 4.2 | 10.1 | 7.4 | 5.1 | 1.0 | 10.0 | 0.9919 | ||||||
5 | Sulfadiazine | Milk | 0.5–20 | 5 | 10 | 20 | 82.3 ± 9.5 | 110.0 ± 7.4 | 97.7 ± 7.4 | 9.5 | 8.2 | 7.8 | 9.4 | 9.7 | 8.4 | 0.5 | 5.0 | 0.9955 |
Milk powder | 74.7 ± 9.2 | 88.6 ± 8.0 | 101.5 ± 3.7 | 9.5 | 8.9 | 4.5 | 9.8 | 9.5 | 5.2 | 0.5 | 5.0 | 0.9992 | ||||||
6 | Sulfapyridine | Milk | 0.5–20 | 5 | 10 | 20 | 103.5 ± 8.6 | 109.3 ± 8.8 | 98.2 ± 8.5 | 8.5 | 9.2 | 8.5 | 9.8 | 9.5 | 9.5 | 0.5 | 5.0 | 0.9968 |
Milk powder | 80.8 ± 8.2 | 103.7 ± 3.5 | 93.7 ± 4.9 | 8.8 | 3.9 | 3.2 | 8.5 | 4.4 | 6.0 | 0.5 | 5.0 | 0.9937 | ||||||
7 | Lincomycin | Milk | 0.5–20 | 5 | 10 | 20 | 106.1 ± 9.1 | 108.9 ± 7.0 | 87.6 ± 7.0 | 9.5 | 9.2 | 8.4 | 9.1 | 8.8 | 9.0 | 0.5 | 5.0 | 0.9925 |
Milk powder | 73.6 ± 3.8 | 89.7 ± 3.8 | 97.8 ± 1.6 | 4.5 | 4.1 | 2.3 | 5.9 | 6.2 | 3.4 | 0.5 | 5.0 | 0.9917 | ||||||
8 | Sulfathiazole | Milk | 0.5–20 | 5 | 10 | 20 | 96.0 ± 9.5 | 106.3 ± 8.1 | 98.2 ± 5.4 | 8.9 | 7.5 | 5.1 | 10.5 | 9.2 | 6.4 | 0.5 | 5.0 | 0.9935 |
Milk powder | 75.6 ± 3.2 | 83.6 ± 1.6 | 98.2 ± 3.4 | 4.2 | 2.5 | 4.1 | 5.9 | 3.1 | 5.5 | 0.5 | 5.0 | 0.9906 | ||||||
9 | Sulfamerazine | Milk | 0.5–20 | 5 | 10 | 20 | 93.6 ± 7.9 | 103.6 ± 3.7 | 98.8 ± 8.6 | 8.9 | 3.0 | 7.8 | 9.5 | 4.0 | 9.5 | 0.5 | 5.0 | 0.9936 |
Milk powder | 82.2 ± 7.9 | 94.3 ± 3.9 | 97.2 ± 2.4 | 8.4 | 4.9 | 1.5 | 9.4 | 5.2 | 2.6 | 0.5 | 5.0 | 0.9947 | ||||||
10 | Ampicillin | Milk | 1–100 | 10 | 20 | 50 | 64.7 ± 9.8 | 70.3 ± 9.3 | 91.6 ± 7.2 | 9.1 | 9.5 | 8.2 | 10.2 | 10.1 | 9.5 | 1.0 | 10.0 | 0.9945 |
Milk powder | 63.0 ± 8.8 | 66.9 ± 4.5 | 107.4 ± 0.9 | 9.0 | 5.1 | 1.1 | 10.1 | 5.4 | 2.6 | 1.0 | 10.0 | 0.9902 | ||||||
11 | Penicillin G | Milk | 1–100 | 10 | 20 | 50 | 61.3 ± 9.1 | 62.3 ± 9.2 | 71.5 ± 4.1 | 9.4 | 9.5 | 5.4 | 10.7 | 10.2 | 6.5 | 1.0 | 10.0 | 0.9929 |
Milk powder | 60.7 ± 4.9 | 64.1 ± 3.5 | 66.4 ± 1.3 | 5.2 | 3.9 | 2.1 | 6.2 | 5.1 | 3.8 | 1.0 | 10.0 | 0.9912 | ||||||
12 | Trimethoprim | Milk | 0.5–20 | 5 | 10 | 20 | 92.4 ± 5.8 | 108.4 ± 4.7 | 98.1 ± 5.0 | 6.8 | 5.4 | 4.5 | 7.4 | 6.8 | 5.5 | 0.5 | 5.0 | 0.9933 |
Milk powder | 108.4 ± 5.6 | 97.5 ± 3.5 | 96.7 ± 2.4 | 5.9 | 4.2 | 3.0 | 6.9 | 5.1 | 4.0 | 0.5 | 5.0 | 0.9946 | ||||||
13 | Metronidazole-OH | Milk | 0.5–20 | 5 | 10 | 20 | 103.7 ± 8.5 | 109.1 ± 7.4 | 87.2 ± 9.2 | 8.5 | 7.4 | 10.5 | 9.5 | 8.5 | 11.1 | 0.5 | 5.0 | 0.9958 |
Milk powder | 75.2 ± 3.8 | 77.1 ± 3.5 | 102.0 ± 1.7 | 4.8 | 4.1 | 2.3 | 5.9 | 4.5 | 3.1 | 0.5 | 5.0 | 0.9948 | ||||||
14 | Norfloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 92.2 ± 6.3 | 101.6 ± 4.5 | 85.6 ± 3.1 | 7.3 | 5.5 | 3.2 | 8.1 | 5.6 | 4.8 | 0.5 | 5.0 | 0.9945 |
Milk powder | 79.4 ± 6.2 | 95.7 ± 5.5 | 101.0 ± 4.7 | 6.8 | 5.9 | 4.8 | 7.5 | 6.9 | 5.4 | 0.5 | 5.0 | 0.9942 | ||||||
15 | Lomefloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 106.1 ± 6.5 | 107.1 ± 5.7 | 91.8 ± 4.7 | 7.1 | 6.5 | 5.7 | 8.5 | 7.8 | 6.5 | 0.5 | 5.0 | 0.9937 |
Milk powder | 82.7 ± 8.9 | 84.5 ± 4.5 | 99.5 ± 3.1 | 9.0 | 4.8 | 3.2 | 9.2 | 6.1 | 4.5 | 0.5 | 5.0 | 0.9913 | ||||||
16 | Enoxacin | Milk | 0.5–20 | 5 | 10 | 20 | 83.1 ± 8.7 | 100.6 ± 5.0 | 95.6 ± 5.0 | 9.8 | 6.8 | 4.5 | 9.1 | 7.2 | 6.4 | 0.5 | 5.0 | 0.9946 |
Milk powder | 103.4 ± 8.4 | 104.7 ± 4.6 | 98.9 ± 3.4 | 8.9 | 5.2 | 3.9 | 9.8 | 6.5 | 4.8 | 0.5 | 5.0 | 0.9951 | ||||||
17 | Ofloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 105.3 ± 6.3 | 104.4 ± 3.3 | 94.6 ± 3.0 | 7.4 | 5.6 | 4.5 | 7.8 | 6.2 | 5.2 | 0.5 | 5.0 | 0.9938 |
Milk powder | 108.3 ± 5.3 | 103.2 ± 3.2 | 98.0 ± 3.0 | 5.8 | 4.2 | 3.5 | 6.9 | 5.2 | 4.5 | 0.5 | 5.0 | 0.9976 | ||||||
18 | Pefloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 100.3 ± 8.6 | 109.5 ± 7.8 | 93.2 ± 3.6 | 9.1 | 8.8 | 4.5 | 9.2 | 9.2 | 5.4 | 0.5 | 5.0 | 0.9948 |
Milk powder | 94.3 ± 4.8 | 96.5 ± 1.9 | 99.3 ± 1.2 | 5.0 | 2.1 | 1.5 | 6.5 | 3.5 | 2.9 | 0.5 | 5.0 | 0.9972 | ||||||
19 | Danofloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 87.2 ± 9.7 | 98.2 ± 6.6 | 83.7 ± 8.5 | 9.5 | 7.8 | 7.5 | 8.1 | 7.0 | 8.0 | 0.5 | 5.0 | 0.9948 |
Milk powder | 77.3 ± 7.8 | 85.5 ± 6.3 | 95.2 ± 5.5 | 8.0 | 6.5 | 5.7 | 9.5 | 8.7 | 6.3 | 0.5 | 5.0 | 0.9937 | ||||||
20 | Sulfadimethoxine | Milk | 0.5–20 | 5 | 10 | 20 | 93.1 ± 5.8 | 108.1 ± 3.8 | 101.4 ± 4.2 | 5.5 | 4.1 | 4.5 | 6.0 | 4.5 | 5.2 | 0.5 | 5.0 | 0.9937 |
Milk powder | 85.9 ± 9.1 | 90.6 ± 7.7 | 94.7 ± 4.5 | 9.5 | 7.9 | 4.9 | 9.8 | 9.4 | 7.1 | 0.5 | 5.0 | 0.9914 | ||||||
21 | Sulfamethizole | Milk | 0.5–20 | 5 | 10 | 20 | 106.7 ± 8.0 | 109.4 ± 5.3 | 98.2 ± 4.0 | 9.5 | 6.4 | 5.1 | 9.8 | 7.0 | 5.5 | 0.5 | 5.0 | 0.9920 |
Milk powder | 90.1 ± 9.3 | 102.4 ± 7.2 | 99.6 ± 9.0 | 9.8 | 7.4 | 8.9 | 9.2 | 9.5 | 9.1 | 0.5 | 5.0 | 0.9908 | ||||||
22 | Sulfamethoxydiazine | Milk | 0.5–20 | 5 | 10 | 20 | 101.9 ± 9.3 | 107.6 ± 7.7 | 94.1 ± 8.0 | 9.9 | 8.1 | 7.9 | 9.5 | 8.2 | 9.0 | 0.5 | 5.0 | 0.9936 |
Milk powder | 86.5 ± 9.8 | 95.9 ± 4.6 | 105.3 ± 3.6 | 9.8 | 5.0 | 3.5 | 9.9 | 6.5 | 4.1 | 0.5 | 5.0 | 0.9911 | ||||||
23 | Ciprofloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 98.3 ± 5.8 | 92.9 ± 4.2 | 109.6 ± 3.2 | 6.8 | 5.4 | 4.2 | 7.4 | 5.9 | 5.1 | 0.5 | 5.0 | 0.9947 |
Milk powder | 98.0 ± 8.2 | 99.4 ± 4.4 | 107.5 ± 2.6 | 8.4 | 4.7 | 3.0 | 9.8 | 6.4 | 4.9 | 0.5 | 5.0 | 0.9961 | ||||||
24 | Dimetridazole | Milk | 0.5–20 | 5 | 10 | 20 | 102.8 ±7.5 | 108.3 ± 8.9 | 92.3 ± 9.5 | 8.5 | 8.5 | 9.8 | 8.5 | 9.5 | 9.2 | 0.5 | 5.0 | 0.9909 |
Milk powder | 81.6 ± 4.4 | 108.6 ± 5.5 | 100.9 ± 2.9 | 4.9 | 5.7 | 3.1 | 5.7 | 6.5 | 4.1 | 0.5 | 5.0 | 0.9948 | ||||||
25 | Marbofloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 90.8 ± 8.5 | 108.0 ± 5.1 | 94.8 ± 5.2 | 9.1 | 6.5 | 5.4 | 11.5 | 7.5 | 6.8 | 0.5 | 5.0 | 0.9940 |
Milk powder | 93.5 ± 6.7 | 95.6 ± 6.5 | 100.6 ± 4.6 | 7.0 | 6.8 | 4.9 | 8.9 | 7.9 | 5.8 | 0.5 | 5.0 | 0.9970 | ||||||
26 | Fleroxcain | Milk | 0.5–20 | 5 | 10 | 20 | 71.8 ± 7.7 | 104.0 ± 5.5 | 95.4 ± 6.5 | 8.9 | 6.5 | 7.4 | 8.9 | 8.4 | 7.9 | 0.5 | 5.0 | 0.9938 |
Milk powder | 94.0 ± 8.6 | 95.2 ± 8.9 | 98.3 ± 3.6 | 8.4 | 8.7 | 4.1 | 9.9 | 9.5 | 5.2 | 0.5 | 5.0 | 0.9942 | ||||||
27 | Orbifloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 79.9 ± 9.8 | 102.3 ± 6.3 | 99.5 ± 9.0 | 10.5 | 7.4 | 9.4 | 9.5 | 8.5 | 9.8 | 0.5 | 5.0 | 0.9938 |
Milk powder | 75.4 ± 9.2 | 85.7 ± 7.7 | 95.7 ± 4.9 | 9.5 | 7.9 | 5.1 | 9.8 | 9.1 | 6.8 | 0.5 | 5.0 | 0.9908 | ||||||
28 | Enrofloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 91.2 ± 9.2 | 106.4 ± 9.6 | 88.5 ± 9.3 | 9.5 | 9.8 | 9.9 | 9.1 | 9.9 | 9.5 | 0.5 | 5.0 | 0.9936 |
Milk powder | 80.2 ± 8.0 | 99.7 ± 3.7 | 99.7 ± 1.7 | 9.7 | 4.1 | 1.9 | 9.9 | 5.4 | 2.8 | 0.5 | 5.0 | 0.9968 | ||||||
29 | Sulfamethoxypyridazine | Milk | 0.5–20 | 5 | 10 | 20 | 66.5 ± 8.9 | 103.9 ± 6.0 | 90.6 ± 7.6 | 9.1 | 6.9 | 7.0 | 9.2 | 8.9 | 7.5 | 0.5 | 5.0 | 0.9911 |
Milk powder | 77.2 ± 8.0 | 97.6 ± 7.8 | 108.5 ± 8.0 | 9.2 | 9.4 | 8.5 | 9.1 | 9.5 | 9.4 | 0.5 | 5.0 | 0.9945 | ||||||
30 | Sparfloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 60.6 ± 7.8 | 73.9 ± 6.5 | 86.7 ± 5.6 | 8.2 | 6.9 | 6.5 | 9.5 | 7.2 | 7.0 | 0.5 | 5.0 | 0.9936 |
Milk powder | 83.8 ± 4.5 | 94.7 ± 4.0 | 105.2 ± 3.6 | 4.9 | 4.2 | 4.0 | 5.8 | 5.2 | 5.0 | 0.5 | 5.0 | 0.9925 | ||||||
31 | Demethylchlortetracycline | Milk | 1–100 | 10 | 20 | 50 | 60.6 ± 8.6 | 65.5 ± 7.1 | 78.9 ± 6.5 | 9.5 | 9.5 | 8.4 | 9.1 | 9.5 | 8.1 | 1.0 | 10.0 | 0.9958 |
Milk powder | 75.2 ± 8.4 | 77.7 ± 9.0 | 76.1 ± 8.2 | 8.9 | 10.5 | 9.4 | 9.1 | 9.5 | 7.9 | 1.0 | 10.0 | 0.9954 | ||||||
32 | Sulfachlorpyridazine | Milk | 0.5–20 | 5 | 10 | 20 | 87.9 ± 9.4 | 98.5 ± 7.8 | 99.8 ± 7.7 | 9.5 | 8.2 | 7.9 | 9.1 | 8.0 | 8.0 | 0.5 | 5.0 | 0.9956 |
Milk powder | 68.0 ± 8.2 | 73.1 ± 8.7 | 90.7 ± 8.3 | 8.8 | 8.9 | 9.0 | 9.5 | 9.7 | 9.8 | 0.5 | 5.0 | 0.9980 | ||||||
33 | Difloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 87.4 ± 8.1 | 90.5 ± 9.8 | 87.1 ± 9.1 | 8.5 | 9.1 | 9.5 | 9.0 | 9.5 | 9.5 | 0.5 | 5.0 | 0.9944 |
Milk powder | 85.2 ± 3.4 | 97.0 ± 2.9 | 103.6 ± 2.5 | 3.9 | 2.8 | 2.9 | 4.5 | 3.4 | 3.0 | 0.5 | 5.0 | 0.9942 | ||||||
34 | Chlorotetracycline | Milk | 1–100 | 10 | 20 | 50 | 70.3 ± 9.1 | 72.8 ± 8.3 | 94.7 ± 5.1 | 9.5 | 8.7 | 5.6 | 9.7 | 9.2 | 6.4 | 1.0 | 10.0 | 0.9955 |
Milk powder | 73.4 ± 9.0 | 88.0 ± 9.1 | 85.4 ± 5.7 | 9.5 | 8.7 | 6.5 | 9.7 | 8.9 | 6.8 | 1.0 | 10.0 | 0.9901 | ||||||
35 | Spiramycin | Milk | 1–100 | 10 | 20 | 50 | 71.7 ± 9.6 | 76.6 ± 9.2 | 107.8 ± 8.5 | 9.6 | 8.2 | 9.5 | 9.7 | 8.8 | 9.7 | 1.0 | 10.0 | 0.9928 |
Milk powder | 63.6 ± 6.7 | 102.6 ± 5.8 | 93.7 ± 3.0 | 6.8 | 5.7 | 3.2 | 7.5 | 6.9 | 4.1 | 1.0 | 10.0 | 0.9998 | ||||||
36 | Ipronidazole-OH | Milk | 0.5–20 | 5 | 10 | 20 | 65.9 ± 9.7 | 105.2 ± 7.8 | 89.8 ± 3.0 | 9.9 | 8.8 | 4.0 | 10.9 | 9.4 | 5.5 | 0.5 | 5.0 | 0.9907 |
Milk powder | 71.9 ± 9.4 | 97.9 ± 9.1 | 102.3 ± 7.5 | 9.5 | 9.1 | 8.0 | 10.9 | 10.5 | 9.0 | 0.5 | 5.0 | 0.9924 | ||||||
37 | Sulfadimethoxypyrimidine | Milk | 0.5–20 | 5 | 10 | 20 | 109.6 ± 9.4 | 106.9 ± 9.3 | 96.0 ± 8.7 | 9.4 | 9.6 | 9.0 | 10.5 | 10.3 | 9.5 | 0.5 | 5.0 | 0.9939 |
Milk powder | 73.1 ± 7.6 | 84.1 ± 6.4 | 107.5 ± 6.1 | 7.8 | 6.8 | 6.5 | 8.5 | 7.2 | 7.0 | 0.5 | 5.0 | 0.9951 | ||||||
38 | Sarafloxacin | Milk | 0.5–20 | 5 | 10 | 20 | 82.6 ± 8.9 | 104.1 ± 9.1 | 98.5 ± 9.2 | 8.7 | 8.9 | 8.7 | 9.5 | 9.1 | 9.5 | 0.5 | 5.0 | 0.9942 |
Milk powder | 94.9 ± 6.5 | 97.5 ± 6.0 | 103.5 ± 6.0 | 6.8 | 6.2 | 5.9 | 7.8 | 7.1 | 7.0 | 0.5 | 5.0 | 0.9976 | ||||||
39 | Nafcillin | Milk | 1–100 | 10 | 20 | 50 | 60.5 ± 8.6 | 64.7 ± 4.5 | 87.7 ± 3.6 | 8.5 | 5.1 | 3.7 | 9.5 | 5.5 | 4.5 | 1.0 | 10.0 | 0.9943 |
Milk powder | 60.4 ± 1.0 | 60.1 ± 1.2 | 60.8 ± 1.3 | 1.5 | 1.4 | 1.1 | 2.5 | 2.3 | 2.1 | 1.0 | 10.0 | 0.9904 | ||||||
40 | Clindamycin | Milk | 1–100 | 10 | 20 | 50 | 60.1 ± 8.8 | 71.7 ± 7.9 | 89.9 ± 4.9 | 8.1 | 8.7 | 4.7 | 8.5 | 8.0 | 5.9 | 1.0 | 10.0 | 0.9951 |
Milk powder | 80.6 ± 5.5 | 94.3 ± 3.7 | 92.3 ± 2.5 | 6.0 | 4.0 | 3.0 | 7.8 | 5.4 | 4.2 | 1.0 | 10.0 | 0.9928 | ||||||
41 | Ornidazole | Milk | 0.5–20 | 5 | 10 | 20 | 95.1 ± 9.8 | 108.5 ± 8.7 | 89.2 ± 9.6 | 9.5 | 9.1 | 8.9 | 10.5 | 9.9 | 9.8 | 0.5 | 5.0 | 0.9937 |
Milk powder | 75.4 ± 8.6 | 73.9 ± 7.4 | 103.5 ± 5.6 | 8.5 | 7.3 | 6.1 | 9.2 | 8.2 | 7.5 | 0.5 | 5.0 | 0.9998 | ||||||
42 | Sulfamethoxazole | Milk | 0.5–20 | 5 | 10 | 20 | 81.2 ± 8.5 | 103.8 ± 8.5 | 89.5 ± 9.1 | 8.1 | 8.9 | 9.2 | 9.1 | 9.5 | 9.2 | 0.5 | 5.0 | 0.9927 |
Milk powder | 67.2 ± 9.0 | 81.9 ± 6.4 | 101.0 ± 2.6 | 9.8 | 6.9 | 3.2 | 9.1 | 7.8 | 4.5 | 0.5 | 5.0 | 0.9953 | ||||||
43 | Sulfisoxazole | Milk | 0.5–20 | 5 | 10 | 20 | 60.7 ± 9.5 | 108.4 ± 4.6 | 94.0 ± 5.8 | 9.4 | 5.4 | 5.0 | 9.9 | 6.5 | 6.0 | 0.5 | 5.0 | 0.9910 |
Milk powder | 95.0 ± 9.2 | 90.0 ± 5.6 | 96.2 ± 3.3 | 9.5 | 6.1 | 3.4 | 9.9 | 7.8 | 4.5 | 0.5 | 5.0 | 0.9962 | ||||||
44 | Ipronidazole | Milk | 0.5–20 | 5 | 10 | 20 | 79.3 ± 9.8 | 103.8 ± 9.5 | 95.1 ± 9.2 | 9.4 | 9.1 | 9.8 | 9.2 | 9.5 | 9.0 | 0.5 | 5.0 | 0.9933 |
Milk powder | 84.6 ± 5.6 | 104.6 ± 4.8 | 96.1 ± 3.2 | 5.9 | 5.1 | 3.5 | 7.1 | 6.4 | 4.1 | 0.5 | 5.0 | 0.9915 | ||||||
45 | Doxycycline | Milk | 0.5–20 | 5 | 10 | 20 | 81.4 ± 8.8 | 100.5 ± 8.1 | 95.6 ± 8.4 | 8.2 | 8.5 | 8.4 | 9.1 | 9.5 | 9.1 | 0.5 | 5.0 | 0.9961 |
Milk powder | 91.0 ± 7.8 | 89.3 ± 6.6 | 102.4 ± 4.6 | 8.0 | 6.9 | 5.1 | 9.5 | 7.8 | 5.9 | 0.5 | 5.0 | 0.9910 | ||||||
46 | Ceftiofur | Milk | 1–100 | 10 | 20 | 50 | 91.5 ± 9.5 | 98.2 ± 7.6 | 105.1 ± 5.5 | 9.6 | 8.1 | 5.6 | 9.7 | 9.1 | 6.1 | 1.0 | 10.0 | 0.9931 |
Milk powder | 93.2 ± 2.7 | 104.7 ± 1.8 | 100.1 ± 1.3 | 2.9 | 1.9 | 1.5 | 3.5 | 2.9 | 4.1 | 1.0 | 10.0 | 0.9916 | ||||||
47 | Sulfaquinoxaline | Milk | 0.5–20 | 5 | 10 | 20 | 82.9 ± 8.7 | 89.0 ± 6.6 | 105.4 ± 5.5 | 9.1 | 6.8 | 6.1 | 9.8 | 7.2 | 6.5 | 0.5 | 5.0 | 0.9953 |
Milk powder | 81.8 ± 9.0 | 93.1 ± 8.8 | 98.3 ± 7.9 | 9.5 | 9.0 | 8.0 | 9.5 | 9.8 | 9.0 | 0.5 | 5.0 | 0.9960 | ||||||
48 | Sulfaphenazole | Milk | 0.5–20 | 5 | 10 | 20 | 98.5 ± 6.9 | 93.1 ± 4.5 | 86.9 ± 5.1 | 7.9 | 5.0 | 5.6 | 8.2 | 6.2 | 5.9 | 0.5 | 5.0 | 0.9937 |
Milk powder | 87.4 ± 9.6 | 94.0 ± 6.4 | 101.3 ± 4.8 | 9.8 | 6.5 | 5.0 | 10.2 | 7.0 | 6.5 | 0.5 | 5.0 | 0.9958 | ||||||
49 | Sulfadimoxine | Milk | 0.5–20 | 5 | 10 | 20 | 82.6 ± 8.9 | 95.5 ± 7.4 | 88.8 ± 8.2 | 8.5 | 8.4 | 8.1 | 9.2 | 9.2 | 8.7 | 0.5 | 5.0 | 0.9954 |
Milk powder | 87.1 ± 8.7 | 91.2 ± 6.3 | 96.9 ± 2.9 | 8.8 | 6.5 | 3.1 | 8.9 | 7.5 | 4.3 | 0.5 | 5.0 | 0.9937 | ||||||
50 | Erythromycin | Milk | 1–100 | 10 | 20 | 50 | 62.1 ± 8.4 | 64.3 ± 7.4 | 84.8 ± 5.4 | 8.1 | 8.4 | 5.5 | 9.0 | 8.9 | 5.5 | 1.0 | 10.0 | 0.9906 |
Milk powder | 78.8 ± 8.2 | 71.5 ± 7.9 | 78.0 ± 6.7 | 8.9 | 8.0 | 6.9 | 9.9 | 9.1 | 7.8 | 1.0 | 10.0 | 0.9903 | ||||||
51 | Tilmicosin | Milk | 1–100 | 10 | 20 | 50 | 77.3 ± 8.5 | 80.0 ± 7.5 | 108.6 ± 7.1 | 8.1 | 7.5 | 8.1 | 9.1 | 7.5 | 8.9 | 1.0 | 10.0 | 0.9928 |
Milk powder | 85.3 ± 8.2 | 109.2 ± 6.0 | 92.8 ± 6.2 | 8.5 | 6.5 | 6.0 | 9.7 | 7.8 | 7.1 | 1.0 | 10.0 | 0.9931 | ||||||
52 | PenicillinV | Milk | 1–100 | 10 | 20 | 50 | 61.9 ± 8.3 | 69.8 ± 7.3 | 79.7 ± 5.5 | 8.6 | 7.1 | 6.1 | 9.5 | 9.5 | 6.8 | 1.0 | 10.0 | 0.9971 |
Milk powder | 71.5 ± 9.4 | 76.9 ± 7.9 | 94.8 ± 3.0 | 9.5 | 9.1 | 3.2 | 9.5 | 9.9 | 4.5 | 1.0 | 10.0 | 0.9903 | ||||||
53 | Tylosin | Milk | 1–100 | 10 | 20 | 50 | 63.0 ± 5.5 | 67.8 ± 4.1 | 94.5 ± 3.8 | 5.4 | 4.2 | 3.9 | 6.8 | 5.9 | 4.9 | 1.0 | 10.0 | 0.9943 |
Milk powder | 88.2 ± 8.6 | 98.2 ± 7.4 | 90.8 ± 3.4 | 8.8 | 7.8 | 3.5 | 9.9 | 8.5 | 4.0 | 1.0 | 10.0 | 0.9948 | ||||||
54 | Flumequine | Milk | 0.5–20 | 5 | 10 | 20 | 73.4 ± 5.4 | 103.4 ± 4.9 | 85.1 ± 3.6 | 6.1 | 5.1 | 3.9 | 7.8 | 6.9 | 5.5 | 0.5 | 5.0 | 0.9944 |
Milk powder | 88.7 ± 6.0 | 101.0 ± 4.5 | 109.1 ± 2.6 | 6.5 | 4.9 | 3.1 | 7.8 | 5.9 | 5.0 | 0.5 | 5.0 | 0.9961 | ||||||
55 | Nalidixicacid | Milk | 0.5–20 | 5 | 10 | 20 | 89.3 ± 9.9 | 90.5 ± 8.6 | 85.2 ± 3.3 | 10.1 | 8.7 | 3.4 | 9.1 | 9.2 | 3.5 | 0.5 | 5.0 | 0.9959 |
Milk powder | 86.6 ± 8.4 | 88.8 ± 3.3 | 102.2 ± 2.1 | 9.0 | 3.8 | 2.5 | 9.9 | 4.8 | 3.1 | 0.5 | 5.0 | 0.9938 | ||||||
56 | Oxacillin | Milk | 1–100 | 10 | 20 | 50 | 90.8 ± 7.7 | 93.7 ± 5.2 | 103.3 ± 4.5 | 7.8 | 5.3 | 4.9 | 9.8 | 6.5 | 5.9 | 1.0 | 10.0 | 0.9950 |
Milk powder | 64.7 ± 9.5 | 85.1 ± 9.8 | 102.7 ± 1.8 | 9.9 | 9.1 | 2.5 | 9.4 | 9.0 | 3.5 | 1.0 | 10.0 | 0.9919 | ||||||
57 | Cloxacillin | Milk | 1–100 | 10 | 20 | 50 | 70.3 ± 7.9 | 82.2 ± 6.5 | 83.7 ± 3.5 | 7.5 | 6.4 | 3.2 | 8.9 | 7.2 | 4.9 | 1.0 | 10.0 | 0.9959 |
Milk powder | 63.9 ± 6.3 | 64.5 ± 6.0 | 82.5 ± 3.9 | 6.8 | 6.5 | 4.1 | 7.8 | 7.0 | 5.4 | 1.0 | 10.0 | 0.9910 | ||||||
58 | Dicloxacillin | Milk | 1–100 | 10 | 20 | 50 | 94.7 ± 9.4 | 103.1 ± 7.2 | 101.5 ± 7.2 | 9.5 | 8.2 | 8.1 | 9.9 | 9.5 | 9.0 | 1.0 | 10.0 | 0.9996 |
Milk powder | 62.5 ± 9.7 | 68.5 ± 8.1 | 94.0 ± 5.6 | 9.9 | 8.4 | 5.8 | 9.1 | 9.8 | 6.4 | 1.0 | 10.0 | 0.9906 | ||||||
59 | Roxithromycin | Milk | 1–100 | 10 | 20 | 50 | 82.9 ± 9.2 | 86.4 ± 7.7 | 103.8 ± 6.5 | 9.8 | 7.8 | 6.4 | 9.5 | 8.5 | 7.2 | 1.0 | 10.0 | 0.9946 |
Milk powder | 77.8 ± 4.7 | 100.1 ± 2.6 | 102.1 ± 2.0 | 5.1 | 2.9 | 2.5 | 6.5 | 3.8 | 3.1 | 1.0 | 10.0 | 0.9905 | ||||||
60 | Josamycin | Milk | 0.5–20 | 5 | 10 | 20 | 66.8 ± 8.5 | 108.1 ± 6.3 | 96.0 ± 3.8 | 9.5 | 7.5 | 4.2 | 8.7 | 8.9 | 6.1 | 0.5 | 5.0 | 0.9948 |
Milk powder | 78.1 ± 4.0 | 86.7 ± 2.0 | 95.7 ± 3.0 | 4.5 | 2.5 | 3.9 | 5.9 | 3.8 | 4.8 | 0.5 | 5.0 | 0.9944 | ||||||