Table 3 Comparison of the calibration curves and calculation of matrix effect (ME) for N-nitrosamines in solvent and in sartan matrices
Analyte | Calibration (matrix) | Linearity range (ng·mL−1) | Regression equation | R2 | ME |
|---|---|---|---|---|---|
NDMA | Methanol | 3 ~ 60 | y = 0.0122x−0.0054 | 0.9989 | |
Candesartan cilexetil | y = 0.0121x−0.0037 | 0.9994 | −0.82% | ||
Olmesartan medoxomi | y = 0.0121x−0.0047 | 0.9988 | −0.82% | ||
Irbesartan | y = 0.0120x−0.0012 | 0.9958 | −1.64% | ||
Valsartan | y = 0.0118x + 0.0162 | 0.9981 | −3.28% | ||
NDEA | Methanol | 0.8 ~ 16 | y = 0.0127x−0.0025 | 0.9976 | |
Candesartan cilexetil | y = 0.0189x−0.0015 | 0.9981 | 48.82% | ||
Olmesartan medoxomi | y = 0.0130x + 0.0009 | 0.9989 | 2.36% | ||
Irbesartan | y = 0.0126x + 0.1833 | 0.9934 | −0.79% | ||
Valsartan | y = 0.0153x−0.0159 | 0.9952 | 20.47% | ||
NDIPA | methanol | 3 ~ 60 | y = 0.0109x−0.0094 | 0.9987 | |
Candesartan cilexetil | y = 0.0115x−0.0052 | 0.9993 | 5.50% | ||
Olmesartan medoxomi | y = 0.0140x−0.0120 | 0.9966 | 28.44% | ||
Irbesartan | y = 0.0109x−0.0124 | 0.9948 | 0.00% | ||
Valsartan | y = 0.0114x−0.0079 | 0.9985 | 4.59% | ||
NDBA | Methanol | 6 ~ 60 | y = 0.0039x−0.0014 | 0.9976 | |
Candesartan cilexetil | y = 0.0042x−0.0006 | 0.9994 | 7.69% | ||
Olmesartan medoxomi | y = 0.0042x−0.0019 | 0.9989 | 7.69% | ||
Irbesartan | y = 0.0034x + 0.0634 | 0.9656 | −12.82% | ||
Valsartan | y = 0.0061x + 0.0200 | 0.9940 | 56.41% |