Table 1 Summary of degradation behaviour of VEN
Sr.no. | Degradation study | Conditions of stress study | % Drug degraded | Retention time of degradants (minutes) |
|---|---|---|---|---|
1. | Acidic hydrolysis | 2N HCl for 72hrs | 7.31% | DP1 at 16.1 min |
2. | Basic hydrolysis | 2N NaOH for 72hrs | No degradation | - |
3. | Neutral hydrolysis | Water for 72hrs | No degradation | - |
4. | Oxidative degradation | 0.3% H2O2 for 48hrs | 44.46% | DP2 at 4.2 min and DP3 at 6.5 min. |
5. | Thermal degradation | 80°C for 7days | No degradation | - |
6. | Photolytic degradation | UV and fluorescent light for 5 cycles | No degradation | - |