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Table 6 Face-centered CCD ANOVA results for peak area

From: Application of Plackett-Burman and central composite designs for screening and optimization of factor influencing the chromatographic conditions of HPTLC method for quantification of efonidipine hydrochloride

Source

Sum of square

Df

Mean square

F value

p value > F

Model

1.064E+007

5

2.129E+006

41.19

0.0001

X1

2.654E+005

1

2.654E+005

5.14

0.0578

X2

2.885E+006

1

2.885E+006

55.83

0.0001

X1 X2

2.127E+006

1

2.127E+006

41.16

0.0004

X12

1.283E+005

1

1.283E+005

2.48

0.1592

X22

3.919E+006

1

3.919E+006

74.84

0.0001

Residual

3.617E+005

7

51674.84

  

Lack of fit

3.263E+005

3

1.088E+005

12.29

0.0174

Pure error

35393.43

4

8848.36

  

Total

1.100E+007

12

   
  1. Df Degrees of freedom