Table 4 Renal extraction rate of EVT201 and its two metabolites
Compound | 0.5 mg (%) | 1.0 mg (%) | 2.5 mg (%) | 5.0 mg (%) |
|---|---|---|---|---|
EVT201 | 1.6 | 2.6 | 1.9 | 2.1 |
Ro46-1927 | 3.1 | 2.8 | 4.7 | 3.0 |
Ro18-5528 | 0.1 | 0.1 | 0.1 | 0.1 |
Total extraction rate | 4.8 | 5.5 | 6.7 | 5.2 |
Compound | 0.5 mg (%) | 1.0 mg (%) | 2.5 mg (%) | 5.0 mg (%) |
|---|---|---|---|---|
EVT201 | 1.6 | 2.6 | 1.9 | 2.1 |
Ro46-1927 | 3.1 | 2.8 | 4.7 | 3.0 |
Ro18-5528 | 0.1 | 0.1 | 0.1 | 0.1 |
Total extraction rate | 4.8 | 5.5 | 6.7 | 5.2 |