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Table 1 The result of topotecan loading studies on the MD3

From: Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

pH Time (min) Lactone(mM) Carboxylate(mM) Loaded drug (mM)a ± SD.b Loading capacity (mg/g)
5 0.5 0.0788 0 0.0392 ± 0.0017 1.44
1 0.0768 0.0047 0.0365 ± 0.0012 1.34
2 0.0751 0.0049 0.0379 ± 0.0020 1.39
3 0.0738 0.0052 0.0390 ± 0.0011 1.43
4 0.0723 0.0059 0.0398 ± 0.0018 1.46
5 0.0704 0.0062 0.0414 ± 0.0019 1.52
5.5 0.5 0.0659 0 0.0521 ± 0.0023 1.91
1 0.0636 0.0065 0.0479 ± 0.0018 1.75
2 0.0617 0.0067 0.0496 ± 0.0019 1.82
3 0.0594 0.0071 0.0515 ± 0.0023 1.89
4 0.0585 0.0074 0.0521 ± 0.0030 1.91
5 0.0570 0.0077 0.0534 ± 0.0026 1.96
6 0.5 0.0498 0 0.0682 ± 0.0020 2.50
1 0.0467 0.0089 0.0624 ± 0.0020 2.29
2 0.0423 0.0094 0.0663 ± 0.0018 2.43
3 0.0389 0.0097 0.0694 ± 0.0019 2.54
4 0.0373 0.0117 0.0690 ± 0.0021 2.53
5 0.0362 0.0165 0.0653 ± 0.0022 2.39
  1. aMean
  2. bStandard deviation (n = 3)