Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

Journal of Analytical Science and Technology

Table 1 The result of topotecan loading studies on the MD₃

pH	Time (min)	Lactone(mM)	Carboxylate(mM)	Loaded drug (mM)^a ± SD.^b	Loading capacity (mg/g)
5	0.5	0.0788	0	0.0392 ± 0.0017	1.44
	1	0.0768	0.0047	0.0365 ± 0.0012	1.34
	2	0.0751	0.0049	0.0379 ± 0.0020	1.39
	3	0.0738	0.0052	0.0390 ± 0.0011	1.43
	4	0.0723	0.0059	0.0398 ± 0.0018	1.46
	5	0.0704	0.0062	0.0414 ± 0.0019	1.52
5.5	0.5	0.0659	0	0.0521 ± 0.0023	1.91
	1	0.0636	0.0065	0.0479 ± 0.0018	1.75
	2	0.0617	0.0067	0.0496 ± 0.0019	1.82
	3	0.0594	0.0071	0.0515 ± 0.0023	1.89
	4	0.0585	0.0074	0.0521 ± 0.0030	1.91
	5	0.0570	0.0077	0.0534 ± 0.0026	1.96
6	0.5	0.0498	0	0.0682 ± 0.0020	2.50
	1	0.0467	0.0089	0.0624 ± 0.0020	2.29
	2	0.0423	0.0094	0.0663 ± 0.0018	2.43
	3	0.0389	0.0097	0.0694 ± 0.0019	2.54
	4	0.0373	0.0117	0.0690 ± 0.0021	2.53
	5	0.0362	0.0165	0.0653 ± 0.0022	2.39