Table 6 HPLC data of degradation studies
S. no. | Stress condition | Stress parameters used | Time (h) | Drug peak | Degraded product peaks | ||||
|---|---|---|---|---|---|---|---|---|---|
Rt | Peak intensity | ||||||||
Peak 1 | Peak 2 | ||||||||
Rt | Intensity | Rt | Intensity | ||||||
1 | Acid | 0.1 N HCl | 48 | 5.035 | 594.73 | – | – | – | – |
2 | Base | 0.1 N NaOH | 48 | 5.177 | 364.46 | 2.966 | 312.129 | – | – |
3 | Oxidative | 0.3 % H2O2 | 48 | 5.299 | 1899.8 | 2.519 | 846.61 | 2.979 | 857.45 |
4 | Light | UV light | 48 | 5.150 | 457.29 | – | – | – | – |
5 | Temperature | 60 °C | 48 | 5.140 | 600.41 | 3.033 | 46.65 | – | – |