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Journal of Analytical Science and Technology

Table 4 Mean pharmacokinetic parameters of Solifenacin in rat plasma after oral administration of 4 mg/200 g male rat

From: Bioanalytical method for quantification of Solifenacin in rat plasma by LC-MS/MS and its application to pharmacokinetic study

Pharmacokinetic

Solifenacin values

Parameter

AUC0−t (ng · h/mL)

1,029.81

Cmax (ng/mL)

17.98

AUC0−∞ (ng · h/mL)

1,540.77

Kel (h/1)

0.01433

Tmax (h)

18

T1/2 (h)

48.37

  1. AUC0−∞, area under the curve extrapolated to infinity; AUC0−t, area under the curve up to the last sampling time; Cmax, the maximum plasma concentration; Tmax, the time to reach peak concentration; Kel, the apparent elimination rate constant.
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