Journal of Analytical Science and Technology

Table 6 Distribution of liraglutide in the different regions of the brain following intravenous (IV, 5 mg/kg) and subcutaneous (SC, 500 mg/kg) injections in rats

From: Pharmacokinetics and brain distribution of the therapeutic peptide liraglutide by a novel LC–MS/MS analysis

Brain region	IV (5 mg/kg, n = 6)		SC (500 mg/kg, n = 6)
Brain region	Concentration (ng/g)	K_p	Concentration (ng/g)	K_p
Cerebrum	16.00 ± 4.51	0.00016 ± 0.00005	22.14 ± 7.34	0.00012 ± 0.00004
Cerebellum	26.30 ± 6.84^†	0.00026 ± 0.00007^†	26.26 ± 6.38	0.00014 ± 0.00003
Hypothalamus	31.62 ± 5.74*	0.00031 ± 0.00004*	32.31 ± 9.28	0.00018 ± 0.00005

^†p < 0.05 versus cerebrum; *p < 0.05 versus cerebrum and cerebellum

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