Table 4 Stability (%) of liraglutide in the rat plasma and brain tissue under four different conditions (mean ± SD, n = 3)
Matrix | Concentration (ng/mL) | Short-term stability (%) | Long-term stability (%) | Autosampler stability (%) | Freeze/thaw stability (%) |
|---|---|---|---|---|---|
Plasma | 800 | 103.93 ± 2.51 | 104.84 ± 3.03 | 100.00 ± 3.39 | 100.98 ± 0.67 |
80 | 109.73 ± 4.77 | 106.74 ± 1.75 | 109.32 ± 2.14 | 103.62 ± 2.39 | |
4 | 107.91 ± 8.80 | 111.61 ± 2.09 | 96.93 ± 2.54 | 102.14 ± 9.85 | |
Brain | 160 | 100.63 ± 1.45 | 103.64 ± 4.21 | 104.64 ± 3.02 | 103.07 ± 6.51 |
40 | 96.44 ± 1.96 | 95.28 ± 6.60 | 92.24 ± 8.69 | 86.60 ± 2.99 | |
8 | 109.38 ± 9.94 | 90.42 ± 9.70 | 87.46 ± 11.79 | 92.85 ± 12.34 |