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Table 3 Extraction recovery (%) of liraglutide and the internal standard (IS) in the rat plasma and brain tissue

From: Pharmacokinetics and brain distribution of the therapeutic peptide liraglutide by a novel LC–MS/MS analysis

Matrix

Analyte

Concentration (ng/mL)

Extraction recovery (%)

Plasma

Liraglutide (n = 3)

800

96.58

80

92.17

4

104.59

IS (n = 9)

50

92.61

Brain

Liraglutide (n = 3)

160

98.33

40

99.76

8

94.06

IS (n = 9)

50

95.76