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Table 2 Antimicrobial and hemolytic activities and therapeutic index (TI) of BP100 and BP100-W

From: A short novel antimicrobial peptide BP100-W with antimicrobial, antibiofilm and anti-inflammatory activities designed by replacement with tryptophan

Bacterial strains

MICa (μM)

BP100

BP100-W

Gram-negative bacteria

 Escherichia coli (KCTC 1682)

4

2

 Pseudomonas aeruginosa (KCTC 1637)

16

8

 Salmonella typhimurium (KCTC 1926)

4

4

Gram-positive bacteria

 Bacillus subtilis (KCTC 3068)

8

8

 Staphylococcus epidermidis (KCTC 1917)

4

2

 Staphylococcus aureus (KCTC1621)

4

4

Multidrug-resistant P. aeruginosa (MDRPA)

 MDRPA 1 (CCARM 2095)

16

8

 MDRPA 2 (CCARM 2109)

16

16

Multidrug-resistant S. aureus (MRSA)

 MRSA 1 (CCARM 3089)

32

16

 MRSA 2 (CCARM 3090)

64

32

GM (μM)b

16.8

10.0

MHC (μM)c

512 < 

512 < 

TI (MHC/GM)d

60.9

102.4

  1. aMinimum inhibitory concentration (MIC) was determined as the lowest concentration of the peptide that inhibited bacterial growth
  2. bGeometric mean (GM) denotes the geometric mean of MIC values from the selected bacterial strains
  3. cMinimal hemolytic concentration (MHC) is the peptide concentration that causes 10% hemolysis of sheep red blood cells (sRBCs)
  4. dTherapeutic index (TI) is the ratio of MHC value (μM) to GM (μM)