Table 1 Intra- and inter-day precision and accuracy, recovery and matrix effect of mefatinib in human plasma (n = 6)
Concentration (ng mL−1) | Intra-day | Inter-day | Recovery | Matrix effect | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Mean ± SD (ng mL−1) | Accuracy (Bias %) | Precision (CV %) | Mean ± SD (ng mL−1) | Accuracy (Bias %) | Precision (CV %) | Mean ± SD | Precision (CV %) | Mean ± SD | Precision (CV %) | |
0.500 (LLOQ) | 0.470 ± 0.0129 | − 6.00 | 2.74 | 0.485 ± 0.0202 | − 3.00 | 4.16 | NA | NA | NA | NA |
1.00 (LQC) | 0.976 ± 0.0363 | − 2.40 | 3.72 | 0.971 ± 0.0312 | − 2.90 | 3.21 | 112.09 ± 2.20 | 1.96 | 1.02 ± 0.02 | 1.83 |
16.0 (MQC) | 15.3 ± 0.297 | − 4.38 | 1.94 | 15.2 ± 0.248 | − 5.00 | 1.63 | 112.48 ± 2.50 | 2.22 | NA | NA |
160.0 (HQC) | 157 ± 3.02 | − 2.13 | 1.93 | 155 ± 2.68 | − 3.13 | 1.73 | 113.19 ± 3.17 | 2.80 | 1.01 ± 0.01 | 1.33 |