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Table 4 Pharmacokinetic parameters of alpelisib after intravenous (10 mg/kg) or oral administration (50 mg/kg) in mice (mean ± SD, n = 4)

From: Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study

Parameter

Intravenous

Oral

Tmax (h)

0.875 ± 0.250

Cmax (ng/mL)

11,400 ± 6,000

T1/2 (h)

1.09 ± 0.07

7.86 ± 4.93

AUClast (ng·h/mL)

25,600 ± 5,600

73,500 ± 24,300

AUCinf (ng·h/mL)

25,700 ± 5,700

84,000 ± 16,400

CL (mL/h/kg)

402 ± 85

Vss (mL/kg)

648 ± 87

F (%)a

65.4

  1. aCalculated by (AUCPO/DosePO)/(AUCIV/DoseIV) × 100
  2. AUC, Area under the plasma concentration–time curve; CL, total clearance; Cmax, maximum plasma concentration; F, bioavailability; SD, standard deviation; T1/2, terminal half-life; Tmax, time to reach Cmax; and Vss, steady-state volume of distribution