Fig. 2From: Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic studyTypical multiple reaction monitoring chromatograms of alpelisib and the internal standard (IS; enzalutamide). a Blank mouse plasma; b blank mouse plasma spiked with the IS (300 ng/mL); c lowest limit of quantification (LLOQ; 1 ng/mL) sample in mouse plasma; d mouse plasma sample collected at 1 h after oral administration of alpelisib at a dose of 50 mg/kg in mice; e blank human plasma; f blank human plasma spiked with the IS (300 ng/mL); and g LLOQ (1 ng/mL) sample in human plasmaBack to article page