Table 6 Pharmacokinetic parameters using noncompartmental analysis of AFB1 and AFM1 in rat blood after a single oral dose of AFB1
Pharmacokinetic parameters | Unit | AFB1 | AFM1 |
|---|---|---|---|
Tmax | h | 0.15 ± 0.034 | 0.33 ± 0.10 |
Cmax | ng/ml | 93.42 ± 23.01 | 53.86 ± 12.12 |
T1/2 | h | 7.62 ± 3.61 | 4.74 ± 2.58 |
AUC(0-24 h) | h*ng/ml | 49.59 ± 17.19 | 110.26 ± 36.28 |
AUC (0-∞) | h*ng/ml | 51.26 ± 18.43 | 112.48 ± 36.19 |
CLz/F | l/h/kg | 22.33 ± 9.79 | 9.98 ± 4.21 |
Vz/F | l/kg | 226.46 ± 100.76 | 65.96 ± 38.47 |