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Table 6 Quantification of EtG, NTX, and 6βNTX in urine samples from alcohol abusers (n = 49)

From: Rapid and simple LC–MS/MS determination of urinary ethyl glucuronide, naltrexone, 6β-naltrexol, chlordiazepoxide, and norchlordiazepoxide for monitoring alcohol abuse

Item

EtG

NTX

6βNTX

Concentration (ng/mL)

 Range

6.3–34,654.7

1.5–3683.2

7.3–32,346.4

 Median

227.6

183.4

8629.7

 Mean

4649.8

511.4

9914.9

Normalized valuea (ng/mg Cr)

 Range

11.2–46,033.0

1.1–3671.4

7.7–34,552.0

 Median

183.0

154.0

8464.4

 Mean

4310.8

510.1

9748.3

Frequency of taking drugsb

34

Frequency of drinkingc

8

  1. aAnalyte concentration (ng/mL)/creatinine concentration (mg/dL) × 100
  2. bNumber of samples with concentrations exceeding the cutoff values. The cutoff values for NTX and 6βNTX were set to 10 ng/mL
  3. cNumber of samples with concentrations exceeding the EtG concentration of 1000 ng/mL. It was concluded that the subjects either drank heavily on the day of the test or on the previous day, or drank lightly on the day of the test