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Journal of Analytical Science and Technology

Table 4 Pharmacokinetic parameters of LTZ in SD rats following oral administration

From: A simple, precise, and sensitive HPLC method for quantification of letrozole in rat plasma: development, validation, and preclinical pharmacokinetics

Parameters

Observed values*

Kel (h−1)

0.011 ± 0.001

t1/2 (h)

60.573 ± 3.018

Cmax (μg/mL)

0.415 ± 0.036

Tmax (h)

44.000 ± 9.798

AUC(0-t) (μg h mL−1)

25.007 ± 1.425

AUC(0-∞) (μg h mL−1)

52.541 ± 2.460

MRT (h)

101.900 ± 7.316

  1. AUC(0-t) area under the curve from zero to the last measurable time t, AUC(0-∞) area under the curve from zero to the last detectable time point, Cmax peak plasma concentration, Kel elimination rate constant, MRT mean residence time, t1/2 half-life, Tmax time to reach peak plasma concentration
  2. *All values are expressed as mean ± S.D.; n = 6
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