Table 3 The pharmacokinetic parameters of DMP in rats after a single-dose administration (n = 6)

From: A sensitive HPLC-FLD method for the quantification of 6-O-demethylmenisporphine isolated from Menispermi Rhizoma in rat plasma

Parameters	Oral neat compound (mean ± SD)	Oral MR extract (mean ± SD)
T_max (h)	2.80 ± 0.84	0.85 ± 0.14**
C_max (μg/L)	2232.30 ± 426.73	3407.51 ± 1126.62*
t_1/2z (h)	5.10 ± 2.74	2.81 ± 0.80*
AUC_0–t (μg/L h)	21796.13 ± 6691.11	16311.98 ± 4760.90
AUC_0–∞ (μg/L h)	22064.56 ± 6403.32	16380.38 ± 4770.11
CLz/F (L/h/kg)	0.05 ± 0.01	0.07 ± 0.02
MRT_0–t (h)	8.03 ± 2.20	4.47 ± 1.20*
MRT_0–∞ (h)	8.32 ± 1.95	4.56 ± 1.23**

*p < 0.05, **p < 0.01 compared with neat compound

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