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Table 2 Plackett-Burman design experimental runs for screening the significant independent variables affecting on the responses

From: Application of Plackett-Burman and central composite designs for screening and optimization of factor influencing the chromatographic conditions of HPTLC method for quantification of efonidipine hydrochloride

Run order

Wavelength

Saturation time

Volume of DCM

Volume of triethylamine

Development distance

Activation of plate

Peak area

Retention factor

1

1

1

− 1

1

− 1

− 1

4985.45

0.77

2

− 1

− 1

− 1

− 1

− 1

− 1

6736.95

0.58

3

1

− 1

1

1

− 1

1

5383.96

0.52

4

− 1

1

1

− 1

1

− 1

5565.23

0.5

5

1

− 1

1

− 1

− 1

− 1

5954.12

0.46

6

− 1

− 1

− 1

1

1

1

9045.56

0.43

7

− 1

1

1

1

− 1

1

4005.6

0.49

8

1

− 1

− 1

− 1

1

1

8195.95

0.48

9

1

1

1

− 1

1

1

7902.53

0.47

10

− 1

− 1

1

1

1

− 1

9265.45

0.55

11

− 1

1

− 1

− 1

-1

1

4601.98

0.45

12

1

1

− 1

1

1

− 1

8315.76

0.46