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Table 3 pH values for each mixture at all time points

From: Intravenous patient-controlled analgesia: in vitro stability profiles of mixtures containing fentanyl, hydromorphone, oxycodone, nefopam, ondansetron, and ramosetron

Time after mixing

Mixture 1

Mixture 2

Mixture 3

Mixture 4

Immediately

5.11 ± 0.10

5.04 ± 0.10

4.17 ± 0.06

4.17 ± 0.04

24 h

5.19 ± 0.03

5.08 ± 0.05

4.35 ± 0.02

4.38 ± 0.04

48 h

5.18 ± 0.06

5.04 ± 0.10

4.32 ± 0.02

4.32 ± 0.02

72 h

5.12 ± 0.12

5.04 ± 0.05

4.48 ± 0.08

4.52 ± 0.04

96 h

5.15 ± 0.06

5.02 ± 0.06

4.42 ± 0.08

4.42 ± 0.10

  1. Mixture 1: fentanyl, oxycodone, nefopam, and ondansetron; mixture 2: fentanyl, oxycodone, nefopam, and ramosetron; mixture 3: fentanyl, hydromorphone, nefopam, and ondansetron; mixture 4: fentanyl, hydromorphone, nefopam, and ramosetron. Data are presented as the mean ± standard deviation