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Table 2 Details of the powdered mixtures prepared

From: On-spot quantification of modafinil in generic medicines purchased from the Internet using handheld Fourier transform-infrared, near-infrared and Raman spectroscopy

DN

Modafinil tablet amount (mg)

Diluent

Diluent amount (mg)

Total weight (mg)

API (% m/m)

M1V1

201.3

LAC

0

201.3

62.5

M1V2

181.6

LAC

19.6

201.2

56.4

M1V3

168.5

LAC

32.6

201.1

52.4

M1V4

159.5

LAC

43.3

202.8

49.1

M1V5

151.2

LAC

53.1

204.3

46.2

M1V6

129

LAC

71.7

200.7

40.2

M1V7

110.9

LAC

90.6

201.5

34.4

M1V8

99.3

LAC

98.9

198.2

31.3

M1V9

81

LAC

119.9

201

25.2

M1V10

71.8

LAC

129.7

201.5

22.3

M1V11

50.8

LAC

150

200.8

15.8

M1V12

30.6

LAC

170.7

201.3

9.5

M1V13

0

LAC

199.6

199.6

0

M2V1

169.6

LAC/POV

30.6

200.2

52.9

M2V2

163

LAC/POV/MgS

52.4

215.4

47.3

M2V3

121.9

LAC/POV/MgS/MAI

79.4

201.3

37.8

M2V4

104.1

LAC/POV/MgS/MAI/MCC

97.2

201.3

32.3

M2V5

76.8

LAC/MCC/NaCMC

134.9

211.7

22.7

M2V6

51.8

LAC/POV/MgS/MAI/MCC/NaCMC

158.9

210.7

15.4

M3V1

201.3

0

0

201.3

62.5

M3V2

180.3

LAC

43.2

223.5

50.1

M3V3

134.4

POV

78.8

213.1

39.4

M3V4

100.7

MgS

97.2

197.8

31.8

M3V5

87.2

MAI

128

215.2

25.3

M3V6

71

MCC

149.1

220.1

20.2

M3V7

52.7

NaCMC

154.5

207.2

15.9

  1. DN dilution number, M1 modafinil lactose dilution, M2 modafinil excipients dilution, M3 modafinil excipients sequential addition, LAC lactose, POV povidone, MgS magnesium stearate, MAI maize starch, MCC microcrystalline cellulose, NaCMC sodium carboxymethylcellulose