A new approach for urinary vanillylmandelic acid determination using eVol microextraction by packed sorbent coupled to liquid chromatography-tandem mass spectrometry

Journal of Analytical Science and Technology

Table 2 Deviations from baseline concentrations of VMA for exogenous potential interferences

Substances	Test concentration(μg/mL)	VMA mean(μg/mL)	VMA determined (μg/mL)	VMA deviation (%)
Theobromine	100	2.93	2.87	− 2.0
Theobromine	100	15.8	15.1	− 4.4
Acetaminophen	200	2.93	3.05	4.1
Acetaminophen	200	15.8	16.2	2.5
Labetalol	100	2.93	2.76	− 5.8
Labetalol	100	15.8	16	1.3
Amitriptyline	10	2.93	2.7	− 7.9
Amitriptyline	10	15.8	14.9	− 5.7
Pseudoephedrine	10	2.93	2.79	− 4.8
Pseudoephedrine	10	15.8	15.6	− 1.3
Diphenhydramine	10	2.93	2.96	1.0
Diphenhydramine	10	15.8	15.4	− 2.5
Theophylline	100	2.93	2.9	− 1.0
Theophylline	100	15.8	17	7.6
Carbidopa	100	2.93	2.84	− 3.1
Carbidopa	100	15.8	17.4	10.1
Levodopa	100	2.93	2.89	− 1.4
Levodopa	100	15.8	16	1.3
Salicylic acid	1000	2.93	3.18	8.5
Salicylic acid	1000	15.8	16	1.3
Clonidine	10	2.93	3.13	6.8
Clonidine	10	15.8	17.3	9.5
Isoetharine	100	2.93	2.85	− 2.7
Isoetharine	100	15.8	17.8	12.7
Isoproterenol	100	2.93	2.92	− 0.3
Isoproterenol	100	15.8	15.3	− 3.2
3-O-methyl-dopa	10	2.93	3.11	6.1
3-O-methyl-dopa	10	15.8	16.7	5.7
Methyldopa	100	2.93	2.89	− 1.4
Methyldopa	100	15.8	16.1	1.9
MDA¹	100	2.93	3.37	15.0
MDA¹	100	15.8	17.1	8.2
HMMA²	100	2.93	3.13	6.8
HMMA²	100	15.8	16.5	4.4
PMMA³	100	2.93	2.73	− 6.8
PMMA³	100	15.8	15	− 5.1
(phentermine,MDEA⁵,amphetamine,MDMA⁶,MA⁷) mixture	100	2.93	2.85	− 2.7
(phentermine,MDEA⁵,amphetamine,MDMA⁶,MA⁷) mixture	100	15.8	16.2	2.5
(ibuprofen, naproxen, cotinine, nicotine, caffeine) mixture	1000	2.93	2.86	− 2.4
(ibuprofen, naproxen, cotinine, nicotine, caffeine) mixture	1000	15.8	16.1	1.9
Carbamazepine	1000	2.93	2.76	− 5.8
Carbamazepine	1000	15.8	16.1	1.9