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Table 5 LOQ comparison of MMS, EMS, and IMS with published methods

From: Time-dependent selected reaction monitoring-based GC-MS/MS method for estimation of genotoxic impurities in new antibacterial agent: alalevonadifloxacin mesylate

Technique

LOQ (ng/g)

Reference

MMS

EMS

IMS

GC-MS/MS-direct injection

40

30

30

Liu et al. 2019

LC-MS/MS with ESI

400

400

Kakadiya et al. 2011

LC-MS/MS with APCI

10000

10000

10000

Guo et al. 2014

GC-MS-direct injection

2720

2240

1920

Wollein and Schramek 2012

GC-MS-headspace derivatization

310

60

150

Alzaga et al. 2007

GC-MS/MS with LLE

5

10

20

Present work