Table 4 Method validation summary
Parameter | MMS | EMS | IMS |
|---|---|---|---|
System precision (peak area ratio RSD, %) | 2.19 | 1.54 | 5.31 |
Method precision (RSD, %) | 1.50 | 1.39 | 4.64 |
Linearity (R) | 0.99957 | 0.99932 | 0.99877 |
Mean accuracy (%) (n = 3) | 91.77 | 93.56 | 97.65 |
LOQ (ng/g) | 5 | 10 | 20 |
LOQ (Absolute on column, ng) | 0.01 | 0.02 | 0.04 |
LOD (ng/g) | 2.5 | 5.0 | 10 |
LOD (absolute on column, ng) | 0.006 | 0.01 | 0.02 |
Robustness | Peak area ratio (RSD, %) | ||
Flow rate (+ 10%) | 1.83 | 1.39 | 3.96 |
Flow rate (− 10%) | 1.74 | 1.55 | 4.81 |
Column temperature (+ 2 °C) | 1.93 | 1.77 | 4.39 |
Column temperature (− 2 °C) | 1.88 | 1.63 | 5.11 |