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Table 5 Pharmacokinetic parameters for gastrodin, parishin A, parishin B, parishin C, and parishin E in rats after the oral administration of the extracts of G. elata at 10 g/kg

From: A simplified LC−MS/MS approach for simultaneous quantification and pharmacokinetics of five compounds in rats following oral administration of Gastrodia elata extract

Compounds

Cmax (ng/mL)

Tmax (h)

AUC0-t (ng/mL h)

AUC0-∞ (ng/mL h)

t1/2 (h)

Gastrodin

14,398 ± 1897

0.50 ± 0.18

24,880 ± 3384

24,899 ± 3399

2.37 ± 0.24

Parishin A

107 ± 61

0.75 ± 0.18

176 ± 85

181 ± 49

1.23 ± 0.33

Parishin B

136 ± 51

0.75 ± 0.18

389 ± 147

407 ± 147

1.68 ± 0.41

Parishin C

79 ± 29

0.65 ± 0.29

220 ± 91

227 ± 91

1.45 ± 0.27

Parishin E

728 ± 13

0.80 ± 0.11

3384 ± 717

3390 ± 717

2.61 ± 0.13

  1. Cmax maximum concentration; Tmax time to maximum concentration, AUC0-t area under the concentration-time curve from zero to last sampling time, AUC0-∞ area under the concentration-time curve from zero to infinity;,t1/2 elimination half-life