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Table 4 Stability data for bromophenol-thiosemicarbazone hybrid in rat plasma (n = 3).

From: An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study

Nominal conc. (nmol/L)100100010000
On bench top at room temperature for 3 hConc. (nmol/L)93.6 ± 14.21139 ± 3611196 ± 622
Stability (%)93.6114112
In autosampler maintained at 6 °C for 24 hConc. (nmol/L)97.8 ± 15.61128 ± 63.612023 ± 1112
Stability (%)97.8113120
After 3 freeze/thaw cycles of − 70 ↔ 23 °CConc. (nmol/L)98.8 ± 3.11095 ± 3210965 ± 683
Stability (%)98.8110110
Short term stability ( − 70 °C for 3 days)Conc.(nmol/L)84.1 ± 7.41122 ± 711230 ± 563
Stability (%)84.1112112
Long term stability ( − 70 °C for 30 days)Conc.(nmol/L)92.0 ± 4.61095 ± 7810626 ± 768
Stability (%)90.3113112