Skip to main content

Advertisement

Table 1 Summary of flow-injection analysis single-ion monitoring (FIA-SIM) method versus the internal standard method

From: Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry

 FIA-SIM methodInternal standard method
 GentamicinTobramycinAmikacinGentamicinTobramycin
Selected m/z322324425322324
Internal standard (m/z)Tobramycin (324)Gentamicin (322)
Limit of detection (ng/mL)15115
Linear dynamic range (ng/mL)10–100025–250010–100010–100025–2500
RSD intra-day, n = 5 (%)6.15.211.72.22.9
RSD Inter-day, n = 15 (%)8.07.83.53.8
Concentration in commercial sample (mg/mL)41.3 ± 2.242.2 ± 1.940.5 ± 1.241.0 ± 0.9