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Table 2 The recovery of LTG, MHD, and OXC in human blood plasma (mean ± standard deviation, n = 6)

From: Development and validation of an improved HPLC-UV method for simultaneous determination of lamotrigine and oxcarbazepine and its active metabolite 10,11-dihydro-10-hydroxycarbazepine in human blood plasma and comparison with an UHPLC-MS/MS method

Drug

Analyte concentration (mg/L)

Recovery-analytes (%)

IS normalized recovery (%)

LTG

96

96.416 ± 11.993

107.685 ± 19.554

48

95.532 ± 10.998

104.92 ± 19.041

24

94.036 ± 6.047

101.893 ± 8.805

6

90.742 ± 10.653

96.295 ± 1.431

MHD

96

99.648 ± 12.17

111.04 ± 18.242

48

98.922 ± 10.127

108.393 ± 16.871

24

95.792 ± 6.056

103.762 ± 8.332

6

92.784 ± 10.517

98.514 ± 2.574

OXC

96

97.591 ± 12.581

108.75 ± 18.517

48

96.473 ± 9.032

105.696 ± 15.734

24

95.643 ± 6.356

103.66 ± 9.514

6

89.374 ± 9.427

95.038 ± 5.174

FCZ (IS)

96

90.983 ± 13.712

-

48

92.412 ± 11.783

24

92.782 ± 9.522

6

94.309 ± 11.685

  1. Abbreviations: LTG lamotrigine, MHD 10,11-dihydro-10-hydroxycarbazepine, OXC oxcarbazepine, IS internal standard (fluconazole), CV coefficient of variation