Table 1 The precision and accuracy of LTG, MHD, and OXC in human blood plasma (mean ± standard deviation)
Measurement | Drug | Analyte concentration (mg/L) | Measured concentration (mg/L) | Bias (%) | Coefficient variation (%) |
|---|---|---|---|---|---|
Intra-day, n = 5 | LTG | 96 | 100.015 ± 8.078 | 4.18 | 8.08 |
48 | 46.138 ± 2.457 | − 3.88 | 5.32 | ||
24 | 22.082 ± 0.789 | − 7.99 | 3.57 | ||
6 | 5.703 ± 0.427 | − 4.95 | 7.49 | ||
2.4 | 2.308 ± 0.08 | − 3.84 | 3.45 | ||
MHD | 96 | 98.85 ± 7.1 | 2.97 | 7.18 | |
48 | 46.773 ± 2.372 | − 2.56 | 5.07 | ||
24 | 22.536 ± 0.788 | − 6.10 | 3.49 | ||
6 | 5.89 ± 0.425 | − 1.83 | 7.22 | ||
2.4 | 2.188 ± 0.102 | − 8.84 | 4.67 | ||
OXC | 96 | 99.414 ± 7.201 | 3.56 | 7.24 | |
48 | 47.06 ± 2.307 | − 1.96 | 4.90 | ||
24 | 22.729 ± 0.794 | − 5.30 | 3.49 | ||
6 | 5.953 ± 0.379 | − 0.78 | 6.37 | ||
2.4 | 2.345 ± 0.183 | − 2.30 | 7.79 | ||
Inter-day, n = 60 | LTG | 96 | 98.769 ± 2.952 | 2.88 | 2.99 |
48 | 46.561 ± 1.076 | − 3.00 | 2.31 | ||
24 | 23.337 ± 0.491 | − 2.76 | 2.10 | ||
6 | 5.878 ± 0.091 | − 2.03 | 1.55 | ||
2.4 | 2.337 ± 0.084 | − 2.63 | 3.58 | ||
MHD | 96 | 96.934 ± 2.884 | 0.97 | 2.97 | |
48 | 46.565 ± 1.416 | − 2.99 | 3.04 | ||
24 | 23.468 ± 0.475 | − 2.22 | 2.03 | ||
6 | 6.053 ± 0.128 | 0.89 | 2.12 | ||
2.4 | 2.335 ± 0.117 | − 2.69 | 5.01 | ||
OXC | 96 | 98.103 ± 2.908 | 2.19 | 2.96 | |
48 | 46.931 ± 1.074 | − 2.23 | 2.29 | ||
24 | 23.912 ± 0.473 | − 0.37 | 1.98 | ||
6 | 6.114 ± 0.204 | 1.89 | 3.34 | ||
2.4 | 2.336 ± 0.066 | − 2.68 | 2.83 |