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Table 6 Results of standard addition technique application on Heterosofir Plus® tablets to the simultaneous analysis of SBR and LPV using the proposed chromatographic methods

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method

 

Sample no.

Claimed conc. (μg band− 1)

Pure added conc. (μg band− 1)

Pure found conc. (μg band− 1)

% Recoverya of the added conc.

SBR

LPV

SBR

LPV

SBR

LPV

SBR

LPV

1

4.00

0.90

2.00

0.45

1.98

0.45

99.00

100.00

2

4.00

0.90

4.00

0.90

4.04

0.89

101.00

98.89

3

4.00

0.90

6.00

1.35

6.03

1.33

100.50

98.52

Mean ± SD %

100.17 ± 1.041

99.14 ± 0.771

RP HPLC-UV method

Sample no.

Claimed conc. (μg ml− 1)

Pure added conc.

(μg ml− 1)

Pure found conc.

(μg ml− 1)

% Recoverya of the added conc.

SBR

LPV

SBR

LPV

SBR

LPV

SBR

LPV

1

40.00

9.00

20.00

4.50

19.78

4.52

98.90

100.44

2

40.00

9.00

40.00

9.00

40.02

9.11

100.05

101.22

3

40.00

9.00

60.00

13.50

60.90

13.26

101.50

98.22

Mean ± RSD %

100.15 ± 1.303

99.96 ± 1.557

  1. aMean of three determinations