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Table 6 Results of standard addition technique application on Heterosofir Plus® tablets to the simultaneous analysis of SBR and LPV using the proposed chromatographic methods

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method 
Sample no.Claimed conc. (μg band− 1)Pure added conc. (μg band− 1)Pure found conc. (μg band− 1)% Recoverya of the added conc.
SBRLPVSBRLPVSBRLPVSBRLPV
14.000.902.000.451.980.4599.00100.00
24.000.904.000.904.040.89101.0098.89
34.000.906.001.356.031.33100.5098.52
Mean ± SD %100.17 ± 1.04199.14 ± 0.771
RP HPLC-UV method
Sample no.Claimed conc. (μg ml− 1)Pure added conc.
(μg ml− 1)
Pure found conc.
(μg ml− 1)
% Recoverya of the added conc.
SBRLPVSBRLPVSBRLPVSBRLPV
140.009.0020.004.5019.784.5298.90100.44
240.009.0040.009.0040.029.11100.05101.22
340.009.0060.0013.5060.9013.26101.5098.22
Mean ± RSD %100.15 ± 1.30399.96 ± 1.557
  1. aMean of three determinations