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Table 5 Simultaneous estimation of SBR and LPV in Heterosofir Plus® tablets using the adopted chromatographic methods

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method
Pharmaceutical preparationSample no.Taken amount
(μg band− 1)
Founda amount
(μg band− 1)
% Recovery
SBRLPVSBRLPVSBRLPV
Heterosofir Plus® tablets labeled to contain 400 mg SRB + 90 mg LPV per tablet14.000.904.020.90100.50100.00
28.001.808.101.79101.2599.44
316.003.6015.923.6299.50100.56
Mean ± % RSD100.42 ± 0.878100.00 ± 0.556
RP HPLC-UV method
Pharmaceutical preparationSample no.Taken amount
(μg.ml− 1)
Founda amount
(μg.ml− 1)
% Recovery
SBRLPVSBRLPVSBRLPV
Heterosofir Plus® tablets labeled to contain 400 mg SRB + 90 mg LPV per tablet120.004.5020.144.51100.70100.22
240.009.0040.038.83100.0898.11
380.0018.0079.5217.9299.4099.56
Mean ± % RSD100.06 ± 0.65099.30 ± 1.079
  1. aMean of three determinations