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Table 4 Robustness testinga of the adopted chromatographic methods for the simultaneous estimation of SBR and LPV

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method
ConditionSBRLPV
RfTRsbRfT
Mobile phase ratio (± 0.2 mL)1.5011.3151.5131.4121.543
RP HPLC-UV method
ConditionSBRLPV
RtTNRsbRtTN
Mobile phase ratio (± 2.0 mL)0.7960.3170.3981.5730.8430.4861.059
pH of of the mobile phase (± 0.1 unit)0.2640.3410.4861.5830.3860.5631.251
  1. aRSD% (n = 6)
  2. bResolution to LPV