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Table 3 Simultaneous determination of SBR and LPV in laboratory prepared mixtures by the developed chromatographic methods

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method
Laboratory-prepared mixture% Recoverya
SBR (μg band− 1)LPV (μg band− 1)SBRLPV
8.000.9098.53100.43
4.001.8099.7299.92
4.000.90100.9998.99
4.000.4599.81101.01
2.000.90101.1198.81
Mean ± SD%100.03 ± 1.05999.83 ± 0.936
RP HPLC-UV method
Laboratory-prepared mixture% Recoverya
SBR (μg ml− 1)LPV (μg ml− 1)SBRLPV
80.009.0098.1498.17
40.0018.0099.3298.92
40.009.0099.7299.57
40.004.50100.3898.72
20.009.0098.6198.61
Mean ± SD %99.23 ± 0.88698.80 ± 0.512
  1. aAverage of 3 experiments