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Table 3 Simultaneous determination of SBR and LPV in laboratory prepared mixtures by the developed chromatographic methods

From: Simultaneous chromatographic analysis of Sofosbuvir/Ledipasvir in their combined dosage form: an application to green analytical chemistry

HPTLC-densitometric method

Laboratory-prepared mixture

% Recoverya

SBR (μg band− 1)

LPV (μg band− 1)

SBR

LPV

8.00

0.90

98.53

100.43

4.00

1.80

99.72

99.92

4.00

0.90

100.99

98.99

4.00

0.45

99.81

101.01

2.00

0.90

101.11

98.81

Mean ± SD%

100.03 ± 1.059

99.83 ± 0.936

RP HPLC-UV method

Laboratory-prepared mixture

% Recoverya

SBR (μg ml− 1)

LPV (μg ml− 1)

SBR

LPV

80.00

9.00

98.14

98.17

40.00

18.00

99.32

98.92

40.00

9.00

99.72

99.57

40.00

4.50

100.38

98.72

20.00

9.00

98.61

98.61

Mean ± SD %

99.23 ± 0.886

98.80 ± 0.512

  1. aAverage of 3 experiments