Table 4 Stability of lenalidomide in plasma samples
Nominal concentration (ng/mL) | Obtained concentration (ng/mL) | % CV | % RE |
|---|---|---|---|
Autosampler stability | |||
26.25 | 26.63 ± 0.89 | 3.34 | − 1.46 |
807.64 | 815.27 ± 29.37 | 3.6 | − 0.94 |
Freeze-thaw stability | |||
26.25 | 27.56 ± 0.70 | 2.54 | − 4.99 |
807.64 | 805.36 ± 29.96 | 3.72 | 0.28 |
Bench top stability | |||
26.25 | 27.02 ± 1.17 | 4.33 | − 2.94 |
807.64 | 808.84 ± 6.81 | 0.84 | − 0.15 |
Dry extract stability in room temperature | |||
26.25 | 26.26 ± 1.26 | 4.81 | − 0.04 |
807.64 | 792.79 ± 30.55 | 3.85 | 1.84 |
Long term stability in plasma at 65 days in – 80 °C | |||
26.25 | 25.47 ± 0.36 | 1.42 | 2.95 |
807.64 | 786.65 ± 6.01 | 0.76 | 2.60 |
Long term stability in plasma at 65 days in – 20 °C | |||
26.25 | 25.01 ± 0.49 | 1.96 | 4.71 |
807.64 | 785.27 ± 0.82 | 0.82 | 2.75 |