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Table 4 Stability of lenalidomide in plasma samples

From: Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of lenalidomide in human plasma and its application on bioequivalence studies

Nominal concentration (ng/mL)Obtained concentration (ng/mL)% CV% RE
Autosampler stability
 26.2526.63 ± 0.893.34− 1.46
 807.64815.27 ± 29.373.6− 0.94
Freeze-thaw stability
 26.2527.56 ± 0.702.54− 4.99
 807.64805.36 ± 29.963.720.28
Bench top stability
 26.2527.02 ± 1.174.33− 2.94
 807.64808.84 ± 6.810.84− 0.15
Dry extract stability in room temperature
 26.2526.26 ± 1.264.81− 0.04
 807.64792.79 ± 30.553.851.84
Long term stability in plasma at 65 days in – 80 °C
 26.2525.47 ± 0.361.422.95
 807.64786.65 ± 6.010.762.60
Long term stability in plasma at 65 days in – 20 °C
 26.2525.01 ± 0.491.964.71
 807.64785.27 ± 0.820.822.75