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Table 2 Partition ratio and recovery (%) of daclatasvir a at different IL:ACN ratios and NaCl concentrations

From: Ionic liquid-based vortex-assisted DLLME followed by RP-LC-PDA method for bioassay of daclatasvir in rat serum: application to pharmacokinetics

Conditions Concentration of daclatasvir (mM) Peak area Partition ratio (p) Recovery (%)
  IL Serum IL Serum
IL:ACN (v/v)
 0.11 0.0435 0.0301 1151275 1005199 1.447 52.7
 0.25 0.0524 0.0245 1426919 724542 2.138 65.9
 0.43 0.0720 0.0022 2118122 30648 32.72 98.8
 0.67 0.0627 0.0175 1703875 447811 3.582 80.6
 1.00 0.0560 0.0195 1593382 559283 2.971 75.2
NaCl (%)
 1.0 0.0817 0.0010 2129955 20739 81.7 99.1
 2.0 0.0745 0.0008 2127401 15840 93.1 99.0
 5.0 0.0712 0.0006 2130342 10811 118.6 99.5
 10.0 0.0704 0.0006 2130342 10811 118.6 99.5
  1. aSpiked concentration = 0.0630 mM