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Table 1 Obtained statistical values for the simultaneous analysis of ET and TC multivariate calibration methods (PLS, PCR, and ILS)

From: Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals

Parameters Thiocolchicoside Etodolac
 Concentration range (μg/mL) 1–10 15–75
 Spectral region (nm) 240–440 240–440
Cross-validation results PLS PCR ILS PLS PCR ILS
 Optimum number of factors 4 5 4 6
 Slope 1.0043 0.9925 1.025 0.9974 0.9880 0.9960
 Intercept − 0.0237 0.0003 0.097 0.2963 0.5764 0.0007
R2 0.9998 0.9997 0.9991 0.9999 0.9994 0.9998
 RMSE-CV (μg/mL) 0.3686 0.4113 2.7289 3.6878
 RMSEC 0.2447 0.2620 0.7372 2.3330 2.9049 2.6381
 RMSEP 0.6092 0.3050 5.2988 2.8973
 SEC 0.6036 2.5262
Validation Results
 Slope 0.9956 1.0076 1.010 1.0019 1.0009 1.013
 Intercept 0.0640 − 0.0187 0.018 0.0027 0.1834 0.854
R2 0.9993 0.9992 0.9995 0.9991 0.9993 0.9997
 RMSEC 0.2047 0.2445 0.6036 1.692 1.295 2.5262