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Table 9 Results of effect of variation in organic (methanol) variation

From: A novel UPLC-PDA isocratic method for the quantification fulvestrant in oil-based pre-filled syringe injection matrix formulations

S. No. Name of the parameter Water:ACN:MeOH (300:400:300) Water:ACN:MeOH (300:400:270) Water:ACN:MeOH (300:400:330)
1 Tailing factor for fulvestrant peak 0.95 0.95 0.95
2 % RSD of fulvestrant peak areas for five replicate injections of standard 0.1 0.0 0.1
3 USP plate count for fulvestrant peak 4223 4288 3796
4 % Assay 98.0 97.6 97.6